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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ctsRTranscriptional regulator of stress response (CtsR); Belongs to the CtsR family. (156 aa)    
Predicted Functional Partners:
clpC
ATPase/chaperone ClpC, putative specificity factor for ClpP protease; Belongs to the ClpA/ClpB family.
  
  
 0.969
hrcA
Transcriptional regulator of heat-shock/chaperone genes; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
   
  
 0.809
clpL
ATPase/chaperone ClpL, putative specificity factor for ClpP protease; Belongs to the ClpA/ClpB family.
  
  
 0.802
clpE
ATPase/chaperone ClpE, putative specificity factor for ClpP protease; Belongs to the ClpA/ClpB family.
  
  
 0.778
tnpA1-IS1520
Transposase (orfA) of IS1520 (IS3 family).
      
 0.660
clpP
ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
  
 0.660
asnA2
L-asparaginase.
      
 0.660
LCA_0713
Hypothetical protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
  
     0.551
clpB
Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
  
 0.542
LCA_1682
5 Proteins of unknown function that are similar to other proteins.
 
    0.485
Your Current Organism:
Lactobacillus sakei
NCBI taxonomy Id: 314315
Other names: L. sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei str. 23K, Lactobacillus sakei subsp. sakei strain 23K
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.