pepA_1 protein (beta proteobacterium KB13) - STRING interaction network

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pepA_1

[E] COG0260 Leucyl aminopeptidase; Belongs to the peptidase M17 family. (479 aa)

Predicted Functional Partners:

pepA_2

0.845

gshB

0.823

KB13_812

0.807

glyA

0.797

gshA

0.797

lpdA

0.756

KB13_278

0.597

KB13_296

0.538

aceE

0.527

KB13_1296

0.513

Your Current Organism:

beta proteobacterium KB13

NCBI taxonomy Id: 314607
Other names: b. proteobacterium KB13

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KB13_1296	pepA_1	KB13_1296	KB13_103	Hypothetical protein.	[E] COG0260 Leucyl aminopeptidase; Belongs to the peptidase M17 family.	0.513
KB13_1296	pepA_2	KB13_1296	KB13_654	Hypothetical protein.	Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.513
KB13_278	pepA_1	KB13_278	KB13_103	Deoxyadenosine kinase, putative; [F] COG1428 Deoxynucleoside kinases.	[E] COG0260 Leucyl aminopeptidase; Belongs to the peptidase M17 family.	0.597
KB13_278	pepA_2	KB13_278	KB13_654	Deoxyadenosine kinase, putative; [F] COG1428 Deoxynucleoside kinases.	Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.597
KB13_296	aceE	KB13_296	KB13_474	Dihydrolipoyllysine-residue acetyltransferase component of pyruvatedehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
KB13_296	glyA	KB13_296	KB13_542	Dihydrolipoyllysine-residue acetyltransferase component of pyruvatedehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.433
KB13_296	lpdA	KB13_296	KB13_169	Dihydrolipoyllysine-residue acetyltransferase component of pyruvatedehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	[C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.	0.998
KB13_296	pepA_1	KB13_296	KB13_103	Dihydrolipoyllysine-residue acetyltransferase component of pyruvatedehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	[E] COG0260 Leucyl aminopeptidase; Belongs to the peptidase M17 family.	0.538
KB13_812	gshA	KB13_812	KB13_886	[E] COG0436 Aspartate/tyrosine/aromatic aminotransferase.	Glutamate--cysteine ligase; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.797
KB13_812	lpdA	KB13_812	KB13_169	[E] COG0436 Aspartate/tyrosine/aromatic aminotransferase.	[C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.	0.874
KB13_812	pepA_1	KB13_812	KB13_103	[E] COG0436 Aspartate/tyrosine/aromatic aminotransferase.	[E] COG0260 Leucyl aminopeptidase; Belongs to the peptidase M17 family.	0.807
KB13_812	pepA_2	KB13_812	KB13_654	[E] COG0436 Aspartate/tyrosine/aromatic aminotransferase.	Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.807
aceE	KB13_296	KB13_474	KB13_296	Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Dihydrolipoyllysine-residue acetyltransferase component of pyruvatedehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
aceE	lpdA	KB13_474	KB13_169	Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	[C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.	0.999
aceE	pepA_1	KB13_474	KB13_103	Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	[E] COG0260 Leucyl aminopeptidase; Belongs to the peptidase M17 family.	0.527
glyA	KB13_296	KB13_542	KB13_296	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Dihydrolipoyllysine-residue acetyltransferase component of pyruvatedehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.433
glyA	gshB	KB13_542	KB13_414	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	[HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Belongs to the prokaryotic GSH synthase family.	0.801
glyA	lpdA	KB13_542	KB13_169	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	[C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.	0.908
glyA	pepA_1	KB13_542	KB13_103	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	[E] COG0260 Leucyl aminopeptidase; Belongs to the peptidase M17 family.	0.797
glyA	pepA_2	KB13_542	KB13_654	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.797