STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KB13_1073Transcriptional regulator, LysR family; [K] COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (299 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.791
dnaN
[L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog).
       0.773
pntA_1
NAD(P) transhydrogenase, alpha subunit; [E] COG0686 Alanine dehydrogenase.
       0.752
pntA_2
Pyridine nucleotide transhydrogenase (proton pump), alpha subunit (part2); [C] COG3288 NAD/NADP transhydrogenase alpha subunit.
       0.741
KB13_1167
NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
       0.741
KB13_455
Hypothetical protein.
       0.741
gltB
Glutamate synthase, large subunit; [E] COG0070 Glutamate synthase domain 3.
     
 0.520
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
   
 
 0.466
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.409
Your Current Organism:
beta proteobacterium KB13
NCBI taxonomy Id: 314607
Other names: b. proteobacterium KB13
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