| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KB13_1043 | KB13_114 | KB13_1043 | KB13_114 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | 0.536 |
| KB13_1071 | KB13_114 | KB13_1071 | KB13_114 | TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | 0.625 |
| KB13_1071 | KB13_330 | KB13_1071 | KB13_330 | TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase. | 0.609 |
| KB13_1071 | KB13_394 | KB13_1071 | KB13_394 | TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | Molybdopterin binding domain; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. | 0.661 |
| KB13_1071 | KB13_544 | KB13_1071 | KB13_544 | TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | [GEPR] COG0477 Permeases of the major facilitator superfamily. | 0.609 |
| KB13_1071 | metH | KB13_1071 | KB13_806 | TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.665 |
| KB13_114 | KB13_1043 | KB13_114 | KB13_1043 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.536 |
| KB13_114 | KB13_1071 | KB13_114 | KB13_1071 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | 0.625 |
| KB13_114 | KB13_330 | KB13_114 | KB13_330 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase. | 0.772 |
| KB13_114 | KB13_394 | KB13_114 | KB13_394 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | Molybdopterin binding domain; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. | 0.556 |
| KB13_114 | KB13_544 | KB13_114 | KB13_544 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | [GEPR] COG0477 Permeases of the major facilitator superfamily. | 0.752 |
| KB13_114 | lpdA | KB13_114 | KB13_169 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.442 |
| KB13_114 | metH | KB13_114 | KB13_806 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.642 |
| KB13_114 | msrC | KB13_114 | KB13_1279 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | Hypothetical protein; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase; probable Secreted protein-methione-sulfoxide reductase with methionine-s-sulfoxide and methionine-r-sulfoxide reductase activity putative signal peptide msyqgliylssvailfsassva; EC_number=1.8.4.11. | 0.460 |
| KB13_114 | ribD | KB13_114 | KB13_760 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.450 |
| KB13_330 | KB13_1071 | KB13_330 | KB13_1071 | Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase. | TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | 0.609 |
| KB13_330 | KB13_114 | KB13_330 | KB13_114 | Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase. | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. | 0.772 |
| KB13_330 | KB13_394 | KB13_330 | KB13_394 | Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase. | Molybdopterin binding domain; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. | 0.526 |
| KB13_330 | KB13_544 | KB13_330 | KB13_544 | Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase. | [GEPR] COG0477 Permeases of the major facilitator superfamily. | 0.785 |
| KB13_394 | KB13_1071 | KB13_394 | KB13_1071 | Molybdopterin binding domain; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. | TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. | 0.661 |
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