KB13_114 protein (beta proteobacterium KB13)

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KB13_114

Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin. (147 aa)

Predicted Functional Partners:

KB13_330

0.800

metH

0.799

KB13_544

0.752

tmk

0.707

KB13_1071

0.625

KB13_394

0.555

KB13_1043

0.536

msrC

0.506

ahpC

0.474

ribD

0.437

Your Current Organism:

beta proteobacterium KB13

NCBI taxonomy Id: 314607
Other names: b. proteobacterium KB13

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KB13_1043	KB13_114	KB13_1043	KB13_114	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	0.536
KB13_1071	KB13_114	KB13_1071	KB13_114	TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	0.625
KB13_1071	KB13_330	KB13_1071	KB13_330	TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase.	0.609
KB13_1071	KB13_394	KB13_1071	KB13_394	TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	Molybdopterin binding domain; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.	0.661
KB13_1071	KB13_544	KB13_1071	KB13_544	TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	[GEPR] COG0477 Permeases of the major facilitator superfamily.	0.609
KB13_1071	metH	KB13_1071	KB13_806	TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.746
KB13_114	KB13_1043	KB13_114	KB13_1043	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.536
KB13_114	KB13_1071	KB13_114	KB13_1071	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	0.625
KB13_114	KB13_330	KB13_114	KB13_330	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase.	0.800
KB13_114	KB13_394	KB13_114	KB13_394	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	Molybdopterin binding domain; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.	0.555
KB13_114	KB13_544	KB13_114	KB13_544	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	[GEPR] COG0477 Permeases of the major facilitator superfamily.	0.752
KB13_114	ahpC	KB13_114	KB13_117	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	0.474
KB13_114	metH	KB13_114	KB13_806	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.799
KB13_114	msrC	KB13_114	KB13_1279	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	Hypothetical protein; [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase; probable Secreted protein-methione-sulfoxide reductase with methionine-s-sulfoxide and methionine-r-sulfoxide reductase activity putative signal peptide msyqgliylssvailfsassva; EC_number=1.8.4.11.	0.506
KB13_114	ribD	KB13_114	KB13_760	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	0.437
KB13_114	tmk	KB13_114	KB13_993	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.707
KB13_330	KB13_1071	KB13_330	KB13_1071	Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase.	TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.	0.609
KB13_330	KB13_114	KB13_330	KB13_114	Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase.	Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; [O] COG0450 Peroxiredoxin.	0.800
KB13_330	KB13_394	KB13_330	KB13_394	Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase.	Molybdopterin binding domain; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.	0.525
KB13_330	KB13_544	KB13_330	KB13_544	Nucleotide binding protein; [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase.	[GEPR] COG0477 Permeases of the major facilitator superfamily.	0.786