Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (629 aa)    
Predicted Functional Partners:
KB13_644
Bifunctional thiED protein; [H] COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase.
 
 0.994
thiS
[H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis.
  
  
 0.971
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.965
KB13_1125
[H] COG0352 Thiamine monophosphate synthase.
  
 
 0.951
KB13_136
Hypothetical protein; [H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1; uba/thif-type NAD/fad binding fold.
 
  
 0.861
uppP
Undecaprenol kinase, putative; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.
       0.817
purM
Phosphoribosylformylglycinamidine cyclo-ligase; [O] COG0071 Molecular chaperone (small heat shock protein).
     
  0.797
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
     
  0.797
KB13_20
[O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase.
       0.559
KB13_127
Isochorismatase hydrolase; [Q] COG1335 Amidases related to nicotinamidase.
     
 0.538
Your Current Organism:
beta proteobacterium KB13
NCBI taxonomy Id: 314607
Other names: b. proteobacterium KB13
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.