Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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hflBCell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (631 aa)    
Predicted Functional Partners:
atpA
ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
   
 0.945
KB13_6
HflK protein; HflC and HflK could encode or regulate a protease.
   
 0.934
rrmJ
Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
 
  
 0.929
hflC
HflC protein; HflC and HflK could regulate a protease.
   
 0.904
rpsG
Ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
  
   0.844
rpmF
[J] COG0333 Ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family.
   
 0.838
KB13_709
[F] COG0634 Hypoxanthine-guanine phosphoribosyltransferase.
  
  
 0.835
htpX
Heat shock protein HtpX; [O] COG0501 Zn-dependent protease with chaperone function; Belongs to the peptidase M48B family.
   
 0.827
KB13_690
50S ribosomal protein L17; [J] COG0532 Translation initiation factor 2 (IF-2; GTPase); Belongs to the bacterial ribosomal protein bL17 family.
   
 
 0.823
KB13_1021
30S ribosomal protein S1; [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha).
  
   0.822
Your Current Organism:
beta proteobacterium KB13
NCBI taxonomy Id: 314607
Other names: b. proteobacterium KB13
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