Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KB13_299Inosine-5'-monophosphate dehydrogenase; [R] COG0517 FOG: CBS domain. (143 aa)    
Predicted Functional Partners:
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
 0.898
gltB
Glutamate synthase, large subunit; [E] COG0070 Glutamate synthase domain 3.
    
 0.891
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.866
KB13_1277
Arabinose 5-phosphate isomerase; [R] COG0517 FOG: CBS domain; Belongs to the SIS family. GutQ/KpsF subfamily.
    
  0.835
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
     
 0.651
kdsA
[E] COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the KdsA family.
  
 
 0.604
purB
Adenylosuccinate lyase; [C] COG0114 Fumarase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
 0.575
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
 0.572
dnaQ
DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.
  
 
  0.570
KB13_555
Conserved hypothetical protein; [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily.
       0.560
Your Current Organism:
beta proteobacterium KB13
NCBI taxonomy Id: 314607
Other names: b. proteobacterium KB13
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