| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gltB | guaA | KB13_763 | KB13_1251 | Glutamate synthase, large subunit; [E] COG0070 Glutamate synthase domain 3. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.846 |
| gltB | guaB | KB13_763 | KB13_378 | Glutamate synthase, large subunit; [E] COG0070 Glutamate synthase domain 3. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.801 |
| gltB | pheT | KB13_763 | KB13_1005 | Glutamate synthase, large subunit; [E] COG0070 Glutamate synthase domain 3. | [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.484 |
| gltB | purB | KB13_763 | KB13_1019 | Glutamate synthase, large subunit; [E] COG0070 Glutamate synthase domain 3. | Adenylosuccinate lyase; [C] COG0114 Fumarase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.477 |
| gltB | purH | KB13_763 | KB13_368 | Glutamate synthase, large subunit; [E] COG0070 Glutamate synthase domain 3. | Bifunctional purine biosynthesis protein PurH; [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.710 |
| guaA | gltB | KB13_1251 | KB13_763 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Glutamate synthase, large subunit; [E] COG0070 Glutamate synthase domain 3. | 0.846 |
| guaA | guaB | KB13_1251 | KB13_378 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | pheT | KB13_1251 | KB13_1005 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.895 |
| guaA | purA | KB13_1251 | KB13_459 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.808 |
| guaA | purB | KB13_1251 | KB13_1019 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase; [C] COG0114 Fumarase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.812 |
| guaA | purH | KB13_1251 | KB13_368 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Bifunctional purine biosynthesis protein PurH; [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.825 |
| guaA | pyrD | KB13_1251 | KB13_342 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.826 |
| guaA | ribB | KB13_1251 | KB13_1236 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Riboflavin biosynthesis protein ribAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.515 |
| guaA | rpoB | KB13_1251 | KB13_484 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.891 |
| guaA | surE | KB13_1251 | KB13_664 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.795 |
| guaB | gltB | KB13_378 | KB13_763 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Glutamate synthase, large subunit; [E] COG0070 Glutamate synthase domain 3. | 0.801 |
| guaB | guaA | KB13_378 | KB13_1251 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | pheT | KB13_378 | KB13_1005 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.847 |
| guaB | purA | KB13_378 | KB13_459 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.940 |
| guaB | purB | KB13_378 | KB13_1019 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate lyase; [C] COG0114 Fumarase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.820 |