node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KB13_1253 | KB13_385 | KB13_1253 | KB13_385 | Stage II sporulation protein E; [TK] COG2208 Serine phosphatase RsbU, regulator of sigma subunit. | Conserved hypothetical protein. | 0.675 |
KB13_1253 | cyaK | KB13_1253 | KB13_363 | Stage II sporulation protein E; [TK] COG2208 Serine phosphatase RsbU, regulator of sigma subunit. | [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain). | 0.902 |
KB13_1286 | KB13_385 | KB13_1286 | KB13_385 | Ammonium transporter; [P] COG0004 Ammonia permease. | Conserved hypothetical protein. | 0.498 |
KB13_1286 | ispD | KB13_1286 | KB13_828 | Ammonium transporter; [P] COG0004 Ammonia permease. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.718 |
KB13_1286 | ispF | KB13_1286 | KB13_15 | Ammonium transporter; [P] COG0004 Ammonia permease. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.718 |
KB13_385 | KB13_1253 | KB13_385 | KB13_1253 | Conserved hypothetical protein. | Stage II sporulation protein E; [TK] COG2208 Serine phosphatase RsbU, regulator of sigma subunit. | 0.675 |
KB13_385 | KB13_1286 | KB13_385 | KB13_1286 | Conserved hypothetical protein. | Ammonium transporter; [P] COG0004 Ammonia permease. | 0.498 |
KB13_385 | KB13_934 | KB13_385 | KB13_934 | Conserved hypothetical protein. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.585 |
KB13_385 | cyaK | KB13_385 | KB13_363 | Conserved hypothetical protein. | [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain). | 0.690 |
KB13_385 | hemC | KB13_385 | KB13_16 | Conserved hypothetical protein. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.511 |
KB13_385 | ispD | KB13_385 | KB13_828 | Conserved hypothetical protein. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.467 |
KB13_385 | ispF | KB13_385 | KB13_15 | Conserved hypothetical protein. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.467 |
KB13_934 | KB13_385 | KB13_934 | KB13_385 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Conserved hypothetical protein. | 0.585 |
KB13_934 | hemC | KB13_934 | KB13_16 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
KB13_934 | ispD | KB13_934 | KB13_828 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.453 |
KB13_934 | ispF | KB13_934 | KB13_15 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.452 |
cyaK | KB13_1253 | KB13_363 | KB13_1253 | [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain). | Stage II sporulation protein E; [TK] COG2208 Serine phosphatase RsbU, regulator of sigma subunit. | 0.902 |
cyaK | KB13_385 | KB13_363 | KB13_385 | [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain). | Conserved hypothetical protein. | 0.690 |
hemC | KB13_385 | KB13_16 | KB13_385 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Conserved hypothetical protein. | 0.511 |
hemC | KB13_934 | KB13_16 | KB13_934 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.995 |