Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KB13_410Nitrogen regulation protein NtrB; [T] COG0642 Signal transduction histidine kinase. (353 aa)    
Predicted Functional Partners:
ntrC
Nitrogen regulation protein; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
 0.997
KB13_436
Nitrogen regulatory protein P-II; [J] COG0223 Methionyl-tRNA formyltransferase; Belongs to the P(II) protein family.
   
 0.937
glnA
[R] COG3968 Uncharacterized protein related to glutamine synthetase.
 
  
 0.825
KB13_1057
Two component, sigma54 specific, transcriptional regulator, Fis family; [T] COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains.
 
 0.820
KB13_1267
[E] COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family.
   
 0.784
KB13_207
[T] COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific.
   
 0.780
KB13_276
Two component transcriptional regulator, winged helix family; [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.735
KB13_1159
Two component transcriptional regulator, winged helix family; [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.
 
 
 0.716
KB13_301
Osmolarity sensor protein EnvZ, putative; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation.
  
 
0.705
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
    
 0.682
Your Current Organism:
beta proteobacterium KB13
NCBI taxonomy Id: 314607
Other names: b. proteobacterium KB13
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