Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
queDQueuosine biosynthesis protein QueD; [H] COG0720 6-pyruvoyl-tetrahydropterin synthase. (148 aa)    
Predicted Functional Partners:
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
 
 0.991
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
  
 0.945
folE2
Conserved hypothetical protein TIGR00294; Converts GTP to 7,8-dihydroneopterin triphosphate.
    
 0.911
queF
7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
  
  
 0.817
ntpA
Nudix hydrolase; [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes.
     
  0.797
KB13_814
Cyclic nucleotide-binding domain protein; [T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases.
    
  0.774
KB13_1161
Ste24 endopeptidase; [O] COG0501 Zn-dependent protease with chaperone function.
       0.773
KB13_739
Short-chain dehydrogenase/reductase SDR; [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
  
  0.622
folB
[H] COG1539 Dihydroneopterin aldolase.
  
 
 0.610
KB13_431
[S] COG3117 Uncharacterized protein conserved in bacteria.
  
     0.571
Your Current Organism:
beta proteobacterium KB13
NCBI taxonomy Id: 314607
Other names: b. proteobacterium KB13
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