| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KB13_211 | glyA | KB13_211 | KB13_542 | HAD-superfamily subfamily IB hydrolase; [E] COG0560 Phosphoserine phosphatase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.415 |
| KB13_211 | leuA | KB13_211 | KB13_1170 | HAD-superfamily subfamily IB hydrolase; [E] COG0560 Phosphoserine phosphatase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.776 |
| KB13_211 | pgsA | KB13_211 | KB13_979 | HAD-superfamily subfamily IB hydrolase; [E] COG0560 Phosphoserine phosphatase. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; [I] COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.565 |
| KB13_211 | pssA | KB13_211 | KB13_49 | HAD-superfamily subfamily IB hydrolase; [E] COG0560 Phosphoserine phosphatase. | CDP-diacylglycerol-serine O-phosphatidyltransferase; [I] COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.835 |
| cdsA | pgsA | KB13_991 | KB13_979 | Phosphatidate cytidylyltransferase; [I] COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; [I] COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.887 |
| cdsA | psd | KB13_991 | KB13_78 | Phosphatidate cytidylyltransferase; [I] COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | Phosphatidylserine decarboxylase family protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.403 |
| cdsA | pssA | KB13_991 | KB13_49 | Phosphatidate cytidylyltransferase; [I] COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | CDP-diacylglycerol-serine O-phosphatidyltransferase; [I] COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.871 |
| cysE | glyA | KB13_178 | KB13_542 | Serine O-acetyltransferase; [R] COG0110 Acetyltransferase (isoleucine patch superfamily). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.861 |
| cysE | metX | KB13_178 | KB13_599 | Serine O-acetyltransferase; [R] COG0110 Acetyltransferase (isoleucine patch superfamily). | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.561 |
| cysE | pgsA | KB13_178 | KB13_979 | Serine O-acetyltransferase; [R] COG0110 Acetyltransferase (isoleucine patch superfamily). | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; [I] COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.489 |
| cysE | pssA | KB13_178 | KB13_49 | Serine O-acetyltransferase; [R] COG0110 Acetyltransferase (isoleucine patch superfamily). | CDP-diacylglycerol-serine O-phosphatidyltransferase; [I] COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.797 |
| cysE | serB | KB13_178 | KB13_1252 | Serine O-acetyltransferase; [R] COG0110 Acetyltransferase (isoleucine patch superfamily). | Phosphoserine phosphatase SerB; [V] COG0286 Type I restriction-modification system methyltransferase subunit. | 0.825 |
| cysE | trpB | KB13_178 | KB13_1270 | Serine O-acetyltransferase; [R] COG0110 Acetyltransferase (isoleucine patch superfamily). | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.797 |
| glyA | KB13_211 | KB13_542 | KB13_211 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | HAD-superfamily subfamily IB hydrolase; [E] COG0560 Phosphoserine phosphatase. | 0.415 |
| glyA | cysE | KB13_542 | KB13_178 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine O-acetyltransferase; [R] COG0110 Acetyltransferase (isoleucine patch superfamily). | 0.861 |
| glyA | metX | KB13_542 | KB13_599 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.824 |
| glyA | pgsA | KB13_542 | KB13_979 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; [I] COG0558 Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.490 |
| glyA | pssA | KB13_542 | KB13_49 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol-serine O-phosphatidyltransferase; [I] COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.797 |
| glyA | serB | KB13_542 | KB13_1252 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase SerB; [V] COG0286 Type I restriction-modification system methyltransferase subunit. | 0.917 |
| glyA | trpB | KB13_542 | KB13_1270 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.861 |