hemK protein (beta proteobacterium KB13) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

hemK

Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC. (281 aa)

Predicted Functional Partners:

prfA

0.999

trmB

0.902

hemA

0.831

metH

0.805

metW

0.773

ampG

0.773

metX

0.773

kdsA

0.696

prfB

0.639

metK

0.612

Your Current Organism:

beta proteobacterium KB13

NCBI taxonomy Id: 314607
Other names: b. proteobacterium KB13

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ampG	hemA	KB13_421	KB13_1119	AmpG muropeptide MFS transporter; [GEPR] COG0477 Permeases of the major facilitator superfamily.	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).	0.773
ampG	hemK	KB13_421	KB13_761	AmpG muropeptide MFS transporter; [GEPR] COG0477 Permeases of the major facilitator superfamily.	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	0.773
ampG	metH	KB13_421	KB13_806	AmpG muropeptide MFS transporter; [GEPR] COG0477 Permeases of the major facilitator superfamily.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.750
ampG	metW	KB13_421	KB13_1172	AmpG muropeptide MFS transporter; [GEPR] COG0477 Permeases of the major facilitator superfamily.	Methionine biosynthesis protein MetW; [QR] COG0500 SAM-dependent methyltransferases.	0.794
ampG	metX	KB13_421	KB13_599	AmpG muropeptide MFS transporter; [GEPR] COG0477 Permeases of the major facilitator superfamily.	Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.	0.808
ampG	prfA	KB13_421	KB13_434	AmpG muropeptide MFS transporter; [GEPR] COG0477 Permeases of the major facilitator superfamily.	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	0.773
hemA	ampG	KB13_1119	KB13_421	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).	AmpG muropeptide MFS transporter; [GEPR] COG0477 Permeases of the major facilitator superfamily.	0.773
hemA	hemK	KB13_1119	KB13_761	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	0.831
hemA	metW	KB13_1119	KB13_1172	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).	Methionine biosynthesis protein MetW; [QR] COG0500 SAM-dependent methyltransferases.	0.773
hemA	metX	KB13_1119	KB13_599	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).	Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.	0.773
hemA	prfA	KB13_1119	KB13_434	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	0.843
hemK	ampG	KB13_761	KB13_421	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	AmpG muropeptide MFS transporter; [GEPR] COG0477 Permeases of the major facilitator superfamily.	0.773
hemK	hemA	KB13_761	KB13_1119	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).	0.831
hemK	kdsA	KB13_761	KB13_576	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	[E] COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the KdsA family.	0.696
hemK	metH	KB13_761	KB13_806	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.805
hemK	metK	KB13_761	KB13_139	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.612
hemK	metW	KB13_761	KB13_1172	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	Methionine biosynthesis protein MetW; [QR] COG0500 SAM-dependent methyltransferases.	0.773
hemK	metX	KB13_761	KB13_599	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.	0.773
hemK	prfA	KB13_761	KB13_434	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	0.999
hemK	prfB	KB13_761	KB13_442	Protein methyltransferase HemK; [J] COG2813 16S RNA G1207 methylase RsmC.	Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.	0.639