node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KB13_191 | KB13_217 | KB13_191 | KB13_217 | [R] COG1988 Predicted membrane-bound metal-dependent hydrolases. | Streptomyces cyclase/dehydrase; [I] COG2867 Oligoketide cyclase/lipid transport protein. | 0.484 |
KB13_191 | KB13_836 | KB13_191 | KB13_836 | [R] COG1988 Predicted membrane-bound metal-dependent hydrolases. | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | 0.484 |
KB13_191 | guaA | KB13_191 | KB13_1251 | [R] COG1988 Predicted membrane-bound metal-dependent hydrolases. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.773 |
KB13_191 | guaB | KB13_191 | KB13_378 | [R] COG1988 Predicted membrane-bound metal-dependent hydrolases. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.574 |
KB13_217 | KB13_191 | KB13_217 | KB13_191 | Streptomyces cyclase/dehydrase; [I] COG2867 Oligoketide cyclase/lipid transport protein. | [R] COG1988 Predicted membrane-bound metal-dependent hydrolases. | 0.484 |
KB13_217 | KB13_836 | KB13_217 | KB13_836 | Streptomyces cyclase/dehydrase; [I] COG2867 Oligoketide cyclase/lipid transport protein. | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | 0.873 |
KB13_217 | guaA | KB13_217 | KB13_1251 | Streptomyces cyclase/dehydrase; [I] COG2867 Oligoketide cyclase/lipid transport protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.544 |
KB13_217 | guaB | KB13_217 | KB13_378 | Streptomyces cyclase/dehydrase; [I] COG2867 Oligoketide cyclase/lipid transport protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.684 |
KB13_217 | smpB | KB13_217 | KB13_1199 | Streptomyces cyclase/dehydrase; [I] COG2867 Oligoketide cyclase/lipid transport protein. | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] | 0.596 |
KB13_836 | KB13_191 | KB13_836 | KB13_191 | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | [R] COG1988 Predicted membrane-bound metal-dependent hydrolases. | 0.484 |
KB13_836 | KB13_217 | KB13_836 | KB13_217 | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | Streptomyces cyclase/dehydrase; [I] COG2867 Oligoketide cyclase/lipid transport protein. | 0.873 |
KB13_836 | guaA | KB13_836 | KB13_1251 | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.544 |
KB13_836 | guaB | KB13_836 | KB13_378 | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.684 |
KB13_836 | nqr | KB13_836 | KB13_740 | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | Na-translocating NADH-quinone reductase, Nqr2 subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family. | 0.499 |
KB13_836 | rnfB | KB13_836 | KB13_497 | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | Electron transport complex protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. | 0.800 |
KB13_836 | rnfC | KB13_836 | KB13_1173 | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | Electron transport complex protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | 0.684 |
KB13_836 | rnfE | KB13_836 | KB13_376 | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | NADH-quinone reductase, subunit d; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. | 0.442 |
KB13_836 | rnfG | KB13_836 | KB13_508 | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | Electron transport complex, rnfabcdGe type, g subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family. | 0.779 |
KB13_836 | smpB | KB13_836 | KB13_1199 | Protein YfjF; [S] COG2914 Uncharacterized protein conserved in bacteria; Belongs to the UPF0125 (RnfH) family. | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] | 0.596 |
guaA | KB13_191 | KB13_1251 | KB13_191 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | [R] COG1988 Predicted membrane-bound metal-dependent hydrolases. | 0.773 |