| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KB13_546 | KB13_574 | KB13_546 | KB13_574 | OmpA/MotB; [M] COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins. | Lipoprotein releasing system, transmembrane protein, LolC/E family; [V] COG0577 ABC-type antimicrobial peptide transport system, permease component. | 0.803 |
| KB13_546 | ispE | KB13_546 | KB13_867 | OmpA/MotB; [M] COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.680 |
| KB13_546 | lolA | KB13_546 | KB13_1237 | OmpA/MotB; [M] COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins. | Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). | 0.773 |
| KB13_574 | KB13_546 | KB13_574 | KB13_546 | Lipoprotein releasing system, transmembrane protein, LolC/E family; [V] COG0577 ABC-type antimicrobial peptide transport system, permease component. | OmpA/MotB; [M] COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins. | 0.803 |
| KB13_574 | ispE | KB13_574 | KB13_867 | Lipoprotein releasing system, transmembrane protein, LolC/E family; [V] COG0577 ABC-type antimicrobial peptide transport system, permease component. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.768 |
| KB13_574 | lolA | KB13_574 | KB13_1237 | Lipoprotein releasing system, transmembrane protein, LolC/E family; [V] COG0577 ABC-type antimicrobial peptide transport system, permease component. | Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). | 0.886 |
| KB13_933 | ispE | KB13_933 | KB13_867 | Hypothetical protein. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.768 |
| KB13_933 | prsA | KB13_933 | KB13_451 | Hypothetical protein. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.535 |
| dxr | ispD | KB13_141 | KB13_828 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.983 |
| dxr | ispE | KB13_141 | KB13_867 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.823 |
| dxr | ispF | KB13_141 | KB13_15 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.922 |
| dxr | ispH | KB13_141 | KB13_315 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.842 |
| ispD | dxr | KB13_828 | KB13_141 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.983 |
| ispD | ispE | KB13_828 | KB13_867 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.983 |
| ispD | ispF | KB13_828 | KB13_15 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.999 |
| ispD | ispH | KB13_828 | KB13_315 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.823 |
| ispE | KB13_546 | KB13_867 | KB13_546 | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | OmpA/MotB; [M] COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins. | 0.680 |
| ispE | KB13_574 | KB13_867 | KB13_574 | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Lipoprotein releasing system, transmembrane protein, LolC/E family; [V] COG0577 ABC-type antimicrobial peptide transport system, permease component. | 0.768 |
| ispE | KB13_933 | KB13_867 | KB13_933 | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Hypothetical protein. | 0.768 |
| ispE | dxr | KB13_867 | KB13_141 | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.823 |