STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (420 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 0.999
pyrDI
Diguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate.
 
 0.995
pyrDII
Dihydroorotate dehydrogenase.
  
 
 0.992
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
  
 0.952
pyrF
Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
  
  
 0.945
AKM54102.1
Dihydroorotase.
     
  0.900
AKM54002.1
Hypothetical protein.
       0.574
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.467
AKM53745.1
Cro/Cl family transcriptional regulator.
  
  
 0.448
guaB
Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.435
Your Current Organism:
Spiroplasma eriocheiris
NCBI taxonomy Id: 315358
Other names: CCTCC M 207170, DSM 21848, S. eriocheiris, Spiroplasma eriocheir, Spiroplasma eriocheiris Wang et al. 2011, strain CRAB, strain TDA-040725-5
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