STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alsS_2Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (525 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase, small subunit.
 
 0.985
alsS_1
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
 
     0.976
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.929
safD
Aldehyde dehydrogenase family protein.
 
 
  0.759
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.740
gabD_3
Acyl-CoA reductase.
 
 
  0.734
maeB_1
Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+).
  
 
 0.728
tme
Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+).
  
 
 0.728
maeB_2
Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+).
  
 
 0.728
tdcB_1
Threonine dehydratase.
  
  0.727
Your Current Organism:
Palleronia marisminoris
NCBI taxonomy Id: 315423
Other names: CECT 7066, LMG 22959, LMG:22959, P. marisminoris, Palleronia marisminoris Martinez-Checa et al. 2005 emend. Albuquerque et al. 2015, strain B33
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