vapC2 protein (Rickettsia felis) - STRING interaction network

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vapC2

Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...] (134 aa)

Predicted Functional Partners:

vapB2

0.999

vapB1

0.586

virB6_5

0.547

pta

0.497

ackA

0.497

RF_0272

0.456

RF_0702

0.456

RF_0731

0.456

RF_0137

0.425

RF_0138

0.425

Your Current Organism:

Rickettsia felis

NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RF_0137	RF_0138	RF_0137	RF_0138	Site-specific DNA methylase.	Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.998
RF_0137	vapC2	RF_0137	RF_0095	Site-specific DNA methylase.	Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]	0.425
RF_0138	RF_0137	RF_0138	RF_0137	Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Site-specific DNA methylase.	0.998
RF_0138	vapC2	RF_0138	RF_0095	Site-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]	0.425
RF_0272	RF_0731	RF_0272	RF_0731	Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system.	Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system.	0.821
RF_0272	vapC2	RF_0272	RF_0095	Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system.	Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]	0.456
RF_0702	vapC2	RF_0702	RF_0095	Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system.	Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]	0.456
RF_0731	RF_0272	RF_0731	RF_0272	Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system.	Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system.	0.821
RF_0731	vapC2	RF_0731	RF_0095	Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system.	Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]	0.456
ackA	pta	RF_0097	RF_0096	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Phosphate acetyltransferase Pta.	0.999
ackA	vapB2	RF_0097	RF_0094	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli or S.cerevisiae neutralizes the effect of cognate toxin VapC2, partially inhibits the RNase activity of VapC2. Belongs to the VapB family.	0.497
ackA	vapC2	RF_0097	RF_0095	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]	0.497
pta	ackA	RF_0096	RF_0097	Phosphate acetyltransferase Pta.	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.999
pta	vapB2	RF_0096	RF_0094	Phosphate acetyltransferase Pta.	Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli or S.cerevisiae neutralizes the effect of cognate toxin VapC2, partially inhibits the RNase activity of VapC2. Belongs to the VapB family.	0.497
pta	vapC2	RF_0096	RF_0095	Phosphate acetyltransferase Pta.	Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]	0.497
vapB1	vapB2	RF_0457	RF_0094	Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC1, partially inhibits the RNase activity of VapC1 in vitro.	Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli or S.cerevisiae neutralizes the effect of cognate toxin VapC2, partially inhibits the RNase activity of VapC2. Belongs to the VapB family.	0.567
vapB1	vapC2	RF_0457	RF_0095	Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC1, partially inhibits the RNase activity of VapC1 in vitro.	Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]	0.586
vapB2	ackA	RF_0094	RF_0097	Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli or S.cerevisiae neutralizes the effect of cognate toxin VapC2, partially inhibits the RNase activity of VapC2. Belongs to the VapB family.	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.497
vapB2	pta	RF_0094	RF_0096	Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli or S.cerevisiae neutralizes the effect of cognate toxin VapC2, partially inhibits the RNase activity of VapC2. Belongs to the VapB family.	Phosphate acetyltransferase Pta.	0.497
vapB2	vapB1	RF_0094	RF_0457	Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli or S.cerevisiae neutralizes the effect of cognate toxin VapC2, partially inhibits the RNase activity of VapC2. Belongs to the VapB family.	Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC1, partially inhibits the RNase activity of VapC1 in vitro.	0.567

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