Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RF_0272Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system. (82 aa)    
Predicted Functional Partners:
RF_0271
Toxin of toxin-antitoxin system; Containing PIN domain for nucleic acid binding.
 
  
 0.962
RF_0732
Toxin of toxin-antitoxin system; Containing PIN domain for nucleic acid binding.
 
  
 0.842
RF_0731
Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system.
  
   
 0.821
RF_0701
Toxin of toxin-antitoxin system; Containing PIN domain for nucleic acid binding.
 
  
 0.524
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
       0.523
RF_0274
Unknown.
       0.523
RF_1339
Predicted transcriptional regulator; Containing the CopG/Arc/MetJ DNA-binding domain.
  
     0.501
vapC1
Toxin of toxin-antitoxin system VapC; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli inhibits growth in liquid culture; this toxic effect is neutralized by coexpression with cognate antitoxin VapB1. Its RNase activity is partially inhibited in vitro by VapB1 ; Belongs to the PINc/VapC protein family.
   
 
 0.486
vapC2
Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]
   
 
 0.456
RF_1286
Cytotoxic translational repressor of toxin-antitoxin system RelE; COG2026.
 
   
 0.440
Your Current Organism:
Rickettsia felis
NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2
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