rickA protein (Rickettsia felis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

rickA

Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection. (529 aa)

Predicted Functional Partners:

tolR

0.936

tolQ

0.923

rompB

0.743

tolB

0.689

pld

0.673

tlyC

0.618

dsbA

0.597

sca2

0.589

tlyA

0.588

RF_0063

0.584

Your Current Organism:

Rickettsia felis

NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RF_0063	rickA	RF_0063	RF_0371	Ankyrin repeat.	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	0.584
dsbA	rickA	RF_0662	RF_0371	Thiol:disulfide interchange protein DsbA.	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	0.597
pld	rickA	RF_1297	RF_0371	Phospholipase D (PLD) superfamily protein; Could be a virulence factor; Belongs to the phospholipase D family.	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	0.673
pld	rompB	RF_1297	RF_0205	Phospholipase D (PLD) superfamily protein; Could be a virulence factor; Belongs to the phospholipase D family.	Outer membrane protein B; Cell surface antigen Sca5, 168 kDa.	0.492
pld	tlyA	RF_1297	RF_0876	Phospholipase D (PLD) superfamily protein; Could be a virulence factor; Belongs to the phospholipase D family.	Hemolysin A.	0.618
pld	tlyC	RF_1297	RF_1185	Phospholipase D (PLD) superfamily protein; Could be a virulence factor; Belongs to the phospholipase D family.	Hemolysin C; Belongs to the UPF0053 family. Hemolysin C subfamily.	0.819
rickA	RF_0063	RF_0371	RF_0063	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	Ankyrin repeat.	0.584
rickA	dsbA	RF_0371	RF_0662	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	Thiol:disulfide interchange protein DsbA.	0.597
rickA	pld	RF_0371	RF_1297	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	Phospholipase D (PLD) superfamily protein; Could be a virulence factor; Belongs to the phospholipase D family.	0.673
rickA	rompB	RF_0371	RF_0205	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	Outer membrane protein B; Cell surface antigen Sca5, 168 kDa.	0.743
rickA	sca2	RF_0371	RF_0067	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	Cell surface antigen Sca2; 209 kDa.	0.589
rickA	tlyA	RF_0371	RF_0876	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	Hemolysin A.	0.588
rickA	tlyC	RF_0371	RF_1185	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	Hemolysin C; Belongs to the UPF0053 family. Hemolysin C subfamily.	0.618
rickA	tolB	RF_0371	RF_0492	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	TolB protein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.	0.689
rickA	tolQ	RF_0371	RF_0504	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	TolQ protein.	0.923
rickA	tolR	RF_0371	RF_0505	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	TolR protein.	0.936
rompB	pld	RF_0205	RF_1297	Outer membrane protein B; Cell surface antigen Sca5, 168 kDa.	Phospholipase D (PLD) superfamily protein; Could be a virulence factor; Belongs to the phospholipase D family.	0.492
rompB	rickA	RF_0205	RF_0371	Outer membrane protein B; Cell surface antigen Sca5, 168 kDa.	Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.	0.743
rompB	tlyA	RF_0205	RF_0876	Outer membrane protein B; Cell surface antigen Sca5, 168 kDa.	Hemolysin A.	0.458
rompB	tlyC	RF_0205	RF_1185	Outer membrane protein B; Cell surface antigen Sca5, 168 kDa.	Hemolysin C; Belongs to the UPF0053 family. Hemolysin C subfamily.	0.763

page 1 of 2

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Textmining

Coexpression

Databases

Fusion

© STRING Consortium 2026

Credits

Access

Info

About