STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rickAActin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection. (529 aa)    
Predicted Functional Partners:
tolR
TolR protein.
  
 
 0.944
tolQ
TolQ protein.
  
 
 0.930
RF_0063
Ankyrin repeat.
  
     0.584
pld
Phospholipase D (PLD) superfamily protein; Could be a virulence factor; Belongs to the phospholipase D family.
 
   
 0.544
tolB
TolB protein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
   
 
 0.539
RF_0543
Two-domain glycosyltransferase; Belongs to the glycosyltransferase 2 family.
      
 0.510
pal
Peptidoglycan-associated lipoprotein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
   
 
 0.478
RF_0883
Unknown.
  
     0.474
dsbA
Thiol:disulfide interchange protein DsbA.
   
  
 0.461
RF_0596
Unknown.
  
     0.454
Your Current Organism:
Rickettsia felis
NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2
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