Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
vapB1Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC1, partially inhibits the RNase activity of VapC1 in vitro. (103 aa)    
Predicted Functional Partners:
vapC1
Toxin of toxin-antitoxin system VapC; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli inhibits growth in liquid culture; this toxic effect is neutralized by coexpression with cognate antitoxin VapB1. Its RNase activity is partially inhibited in vitro by VapB1 ; Belongs to the PINc/VapC protein family.
     
 0.882
nuoL3
NADH dehydrogenase I chain N.
       0.780
nuoL2
NADH dehydrogenase I chain L.
       0.634
vapC2
Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]
     
 0.586
ptrB
Protease II.
       0.581
vapB2
Antitoxin of toxin-antitoxin system VapB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli or S.cerevisiae neutralizes the effect of cognate toxin VapC2, partially inhibits the RNase activity of VapC2. Belongs to the VapB family.
      
 0.567
RF_0459
Unknown.
       0.442
Your Current Organism:
Rickettsia felis
NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2
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