lacA protein (Rickettsia felis) - STRING interaction network

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Score

lacA

Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family. (145 aa)

Predicted Functional Partners:

glyA

0.953

prs

0.945

ubiG

0.875

kpsF

0.699

tme

0.681

pdhB

0.627

thyX

0.617

RF_0484

0.581

RF_0485

0.581

nlpD1

0.574

Your Current Organism:

Rickettsia felis

NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RF_0484	RF_0485	RF_0484	RF_0485	Unknown.	Unknown.	0.773
RF_0484	lacA	RF_0484	RF_0486	Unknown.	Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family.	0.581
RF_0484	nlpD1	RF_0484	RF_0487	Unknown.	Membrane proteins related to metalloendopeptidases; Outer membrane antigenic lipoprotein B precursor.	0.432
RF_0485	RF_0484	RF_0485	RF_0484	Unknown.	Unknown.	0.773
RF_0485	lacA	RF_0485	RF_0486	Unknown.	Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family.	0.581
RF_0485	nlpD1	RF_0485	RF_0487	Unknown.	Membrane proteins related to metalloendopeptidases; Outer membrane antigenic lipoprotein B precursor.	0.432
glyA	kpsF	RF_1188	RF_0720	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	KpsF protein; Belongs to the SIS family. GutQ/KpsF subfamily.	0.612
glyA	lacA	RF_1188	RF_0486	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family.	0.953
glyA	pdhB	RF_1188	RF_1019	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Pyruvate dehydrogenase E1 component, beta subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).	0.644
glyA	thyX	RF_1188	RF_0491	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.941
glyA	tme	RF_1188	RF_0584	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Malate oxidoreductase and phosphate acetyltransferase.	0.762
kpsF	glyA	RF_0720	RF_1188	KpsF protein; Belongs to the SIS family. GutQ/KpsF subfamily.	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.612
kpsF	lacA	RF_0720	RF_0486	KpsF protein; Belongs to the SIS family. GutQ/KpsF subfamily.	Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family.	0.699
kpsF	prs	RF_0720	RF_0078	KpsF protein; Belongs to the SIS family. GutQ/KpsF subfamily.	Ribose-phosphate pyrophosphokinase; PRPP synthetase.	0.556
lacA	RF_0484	RF_0486	RF_0484	Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family.	Unknown.	0.581
lacA	RF_0485	RF_0486	RF_0485	Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family.	Unknown.	0.581
lacA	glyA	RF_0486	RF_1188	Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family.	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.953
lacA	kpsF	RF_0486	RF_0720	Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family.	KpsF protein; Belongs to the SIS family. GutQ/KpsF subfamily.	0.699
lacA	nlpD1	RF_0486	RF_0487	Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family.	Membrane proteins related to metalloendopeptidases; Outer membrane antigenic lipoprotein B precursor.	0.574
lacA	pdhB	RF_0486	RF_1019	Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family.	Pyruvate dehydrogenase E1 component, beta subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).	0.627