node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RF_0038 | fmt | RF_0038 | RF_0325 | Dihydrofolate reductase FolA. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.921 |
RF_0038 | glyA | RF_0038 | RF_1188 | Dihydrofolate reductase FolA. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
RF_0038 | thyX | RF_0038 | RF_0491 | Dihydrofolate reductase FolA. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.920 |
RF_0488 | RF_0489 | RF_0488 | RF_0489 | Predicted metal-dependent hydrolase. | Probable antitoxin of toxin-antitoxin stability system. | 0.718 |
RF_0488 | RF_0490 | RF_0488 | RF_0490 | Predicted metal-dependent hydrolase. | Probable toxin of toxin-antitoxin system. | 0.718 |
RF_0488 | lacA | RF_0488 | RF_0486 | Predicted metal-dependent hydrolase. | Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family. | 0.568 |
RF_0488 | thyX | RF_0488 | RF_0491 | Predicted metal-dependent hydrolase. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.681 |
RF_0489 | RF_0488 | RF_0489 | RF_0488 | Probable antitoxin of toxin-antitoxin stability system. | Predicted metal-dependent hydrolase. | 0.718 |
RF_0489 | RF_0490 | RF_0489 | RF_0490 | Probable antitoxin of toxin-antitoxin stability system. | Probable toxin of toxin-antitoxin system. | 0.978 |
RF_0489 | lacA | RF_0489 | RF_0486 | Probable antitoxin of toxin-antitoxin stability system. | Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family. | 0.523 |
RF_0489 | thyX | RF_0489 | RF_0491 | Probable antitoxin of toxin-antitoxin stability system. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.723 |
RF_0490 | RF_0488 | RF_0490 | RF_0488 | Probable toxin of toxin-antitoxin system. | Predicted metal-dependent hydrolase. | 0.718 |
RF_0490 | RF_0489 | RF_0490 | RF_0489 | Probable toxin of toxin-antitoxin system. | Probable antitoxin of toxin-antitoxin stability system. | 0.978 |
RF_0490 | lacA | RF_0490 | RF_0486 | Probable toxin of toxin-antitoxin system. | Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family. | 0.523 |
RF_0490 | thyX | RF_0490 | RF_0491 | Probable toxin of toxin-antitoxin system. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.723 |
dut | glyA | RF_0620 | RF_1188 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.427 |
dut | thyX | RF_0620 | RF_0491 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.950 |
dut | tmk | RF_0620 | RF_0234 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.958 |
fmt | RF_0038 | RF_0325 | RF_0038 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Dihydrofolate reductase FolA. | 0.921 |
fmt | folD | RF_0325 | RF_0699 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.985 |