Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
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[Homology]
Score
tlpAThiol:disulfide interchange protein TlpA. (215 aa)    
Predicted Functional Partners:
tdpX1
Thioredoxin peroxidase 1.
  
 0.952
RF_0047
Cell surface antigen-like protein Sca10.
  
 0.949
lpdA2
Dihydrolipoamide dehydrogenase.
  
 0.874
lpdA1
Dihydrolipoamide dehydrogenase.
  
 0.874
RF_0960
Sco2 protein precursor; Belongs to the SCO1/2 family.
 
 
 0.866
RF_0043
Sco2 protein precursor; Belongs to the SCO1/2 family.
 
 
 0.840
coxB
Cytochrome c oxidase polypeptide II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).
    
 
 0.832
hscA
Heat shock protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity).
  
 0.831
dnaK
DnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.831
ccmF
Cytochrome c-type biogenesis protein CcmF.
 
  
 0.812
Your Current Organism:
Rickettsia felis
NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2
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