Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
envZOsmolarity sensor protein EnvZ. (437 aa)    
Predicted Functional Partners:
ompR
PetR protein.
 
 0.999
pdhB
Pyruvate dehydrogenase E1 component, beta subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
    
 0.946
czcR
Transcriptional activator protein CzcR.
 
 
 0.909
fadB
3-hydroxyacyl-CoA dehydrogenase FadB; In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
   
 0.907
RF_1050
Regulatory components of sensory transduction system.
 
 
 0.860
ntrX
Nitrogen assimilation regulatory protein NtrX; Member of the two-component regulatory system RF_0895/RF_0427.
 
 
 
 0.777
ntrY
Nitrogen regulation protein NtrY; Member of the two-component regulatory system RF_0427/RF_0895.
 
 
 
 0.767
cycM
Cytochrome c; May be involved in electron transfer from bc1 complex to aa3.
    
 
 0.753
RF_1175
TPR repeats.
  
 0.744
prs
Ribose-phosphate pyrophosphokinase; PRPP synthetase.
   
 0.719
Your Current Organism:
Rickettsia felis
NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.