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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RF_0731Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system. (84 aa)    
Predicted Functional Partners:
RF_0732
Toxin of toxin-antitoxin system; Containing PIN domain for nucleic acid binding.
 
  
 0.962
RF_0271
Toxin of toxin-antitoxin system; Containing PIN domain for nucleic acid binding.
 
  
 0.840
RF_0272
Antitoxin of toxin-antitoxin system Phd; Antitoxin component of a type II toxin-antitoxin (TA) system.
  
   
 0.834
RF_1339
Predicted transcriptional regulator; Containing the CopG/Arc/MetJ DNA-binding domain.
  
     0.649
RF_0701
Toxin of toxin-antitoxin system; Containing PIN domain for nucleic acid binding.
 
  
 0.596
vapC1
Toxin of toxin-antitoxin system VapC; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli inhibits growth in liquid culture; this toxic effect is neutralized by coexpression with cognate antitoxin VapB1. Its RNase activity is partially inhibited in vitro by VapB1 ; Belongs to the PINc/VapC protein family.
   
 
 0.585
vapC2
Toxin of toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its [...]
   
 
 0.583
RF_1206
PIN domain containing protein.
  
     0.526
def2
Polypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. Belongs to the polypeptide deformylase family.
       0.432
RF_0015
Antitoxin of toxin-antitoxin system StbD; Antitoxin component of a type II toxin-antitoxin (TA) system.
 
   
 0.408
Your Current Organism:
Rickettsia felis
NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2
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