iscA2 protein (Rickettsia felis) - STRING interaction network

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Score

iscA2

Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family. (110 aa)

Predicted Functional Partners:

iscU

0.990

hscB

0.979

fdxB

0.893

iscS

0.886

iscR

0.842

spl1

0.840

grxC2

0.824

RF_0267

0.803

gcvT

0.706

hscA

0.661

Your Current Organism:

Rickettsia felis

NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RF_0267	fdxB	RF_0267	RF_1064	NifU-like domain.	Ferredoxin; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.	0.532
RF_0267	gcvT	RF_0267	RF_0811	NifU-like domain.	Glycine cleavage T-protein; Aminomethyl transferase; Belongs to the GcvT family.	0.491
RF_0267	grxC2	RF_0267	RF_1190	NifU-like domain.	Glutaredoxin-like protein grla; Belongs to the glutaredoxin family. Monothiol subfamily.	0.623
RF_0267	hscB	RF_0267	RF_1062	NifU-like domain.	Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	0.481
RF_0267	iscA2	RF_0267	RF_0843	NifU-like domain.	Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family.	0.803
RF_0267	iscS	RF_0267	RF_0845	NifU-like domain.	Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.	0.742
RF_0267	iscU	RF_0267	RF_0844	NifU-like domain.	FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	0.801
RF_0267	spl1	RF_0267	RF_0846	NifU-like domain.	Nifs protein homolog.	0.750
fdxB	RF_0267	RF_1064	RF_0267	Ferredoxin; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.	NifU-like domain.	0.532
fdxB	hscA	RF_1064	RF_1063	Ferredoxin; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.	Heat shock protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity).	0.905
fdxB	hscB	RF_1064	RF_1062	Ferredoxin; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.	Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	0.982
fdxB	iscA2	RF_1064	RF_0843	Ferredoxin; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.	Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family.	0.893
fdxB	iscR	RF_1064	RF_0847	Ferredoxin; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.	Iron-sulfur cluster assembly transcription factor IscR.	0.662
fdxB	iscS	RF_1064	RF_0845	Ferredoxin; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.	Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.	0.940
fdxB	iscU	RF_1064	RF_0844	Ferredoxin; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.	FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	0.994
fdxB	spl1	RF_1064	RF_0846	Ferredoxin; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.	Nifs protein homolog.	0.957
gcvT	RF_0267	RF_0811	RF_0267	Glycine cleavage T-protein; Aminomethyl transferase; Belongs to the GcvT family.	NifU-like domain.	0.491
gcvT	grxC2	RF_0811	RF_1190	Glycine cleavage T-protein; Aminomethyl transferase; Belongs to the GcvT family.	Glutaredoxin-like protein grla; Belongs to the glutaredoxin family. Monothiol subfamily.	0.436
gcvT	iscA2	RF_0811	RF_0843	Glycine cleavage T-protein; Aminomethyl transferase; Belongs to the GcvT family.	Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family.	0.706
gcvT	iscU	RF_0811	RF_0844	Glycine cleavage T-protein; Aminomethyl transferase; Belongs to the GcvT family.	FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	0.461