Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pbpA2Penicillin-binding protein. (561 aa)    
Predicted Functional Partners:
ftsW
Cell division protein FtsW; Belongs to the SEDS family.
 
 
 0.985
mrcA
Penicillin-binding protein 1A family; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
  
 
 0.978
murE
UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.
  
 0.974
ftsQ
Cell division protein FtsQ; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily.
 
 
 0.967
dacF
Penicillin-binding protein DacF precursor; Belongs to the peptidase S11 family.
 
 
 0.953
pbpA1
Penicillin-binding protein.
  
  
0.934
rodA
Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
 
 
 0.932
pbpC
Bifunctional penicillin-binding protein 1C.
     
 0.913
RF_0987
Ankyrin repeat.
  
 
 0.898
murC
UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
 
 
 0.857
Your Current Organism:
Rickettsia felis
NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.