Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
barAHistidine kinase sensor protein. (497 aa)    
Predicted Functional Partners:
RF_1050
Regulatory components of sensory transduction system.
 0.998
ompR
PetR protein.
 
 
 0.958
pdhB
Pyruvate dehydrogenase E1 component, beta subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
   
 0.948
czcR
Transcriptional activator protein CzcR.
 
 
 0.936
fadB
3-hydroxyacyl-CoA dehydrogenase FadB; In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
   
 0.907
cycM
Cytochrome c; May be involved in electron transfer from bc1 complex to aa3.
  
 
 
 0.782
RF_1175
TPR repeats.
  
 0.744
prs
Ribose-phosphate pyrophosphokinase; PRPP synthetase.
    
 0.708
dnaN
DNA polymerase III beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...]
  
  
 0.691
RF_0815
Na+/proline symporter and signal transduction histidine kinase; Sodium:solute symporter family, SSF.
 
 
0.677
Your Current Organism:
Rickettsia felis
NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2
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