node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
icd | pdhB | RF_1015 | RF_1019 | Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Pyruvate dehydrogenase E1 component, beta subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). | 0.817 |
icd | sdhA | RF_1015 | RF_1159 | Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Succinate dehydrogenase flavoprotein subunit. | 0.663 |
icd | sdhB | RF_1015 | RF_0136 | Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.594 |
icd | sucA | RF_1015 | RF_1092 | Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 2-oxoglutarate dehydrogenase E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.951 |
icd | sucC | RF_1015 | RF_0665 | Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.718 |
icd | sucD | RF_1015 | RF_0664 | Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.799 |
lpdA1 | lpdA2 | RF_1270 | RF_0807 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase. | 0.912 |
lpdA1 | pdhB | RF_1270 | RF_1019 | Dihydrolipoamide dehydrogenase. | Pyruvate dehydrogenase E1 component, beta subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). | 0.999 |
lpdA1 | pdhC | RF_1270 | RF_0761 | Dihydrolipoamide dehydrogenase. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). | 0.998 |
lpdA1 | sdhA | RF_1270 | RF_1159 | Dihydrolipoamide dehydrogenase. | Succinate dehydrogenase flavoprotein subunit. | 0.569 |
lpdA1 | sdhB | RF_1270 | RF_0136 | Dihydrolipoamide dehydrogenase. | Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.563 |
lpdA1 | sucA | RF_1270 | RF_1092 | Dihydrolipoamide dehydrogenase. | 2-oxoglutarate dehydrogenase E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). | 0.996 |
lpdA1 | sucB | RF_1270 | RF_1093 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide acetyltransferase component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.997 |
lpdA1 | sucC | RF_1270 | RF_0665 | Dihydrolipoamide dehydrogenase. | Succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.546 |
lpdA1 | sucD | RF_1270 | RF_0664 | Dihydrolipoamide dehydrogenase. | Succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.501 |
lpdA2 | lpdA1 | RF_0807 | RF_1270 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase. | 0.912 |
lpdA2 | pdhB | RF_0807 | RF_1019 | Dihydrolipoamide dehydrogenase. | Pyruvate dehydrogenase E1 component, beta subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). | 0.999 |
lpdA2 | pdhC | RF_0807 | RF_0761 | Dihydrolipoamide dehydrogenase. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). | 0.998 |
lpdA2 | sdhA | RF_0807 | RF_1159 | Dihydrolipoamide dehydrogenase. | Succinate dehydrogenase flavoprotein subunit. | 0.569 |
lpdA2 | sdhB | RF_0807 | RF_0136 | Dihydrolipoamide dehydrogenase. | Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.563 |