| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RF_0260 | gmk | RF_0260 | RF_1229 | TPR repeats. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.470 |
| RF_0260 | groEL | RF_0260 | RF_0409 | TPR repeats. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.609 |
| RF_0260 | htpG | RF_0260 | RF_1333 | TPR repeats. | Heat shock protein HtpG; Molecular chaperone. Has ATPase activity. | 0.863 |
| RF_0260 | pepA | RF_0260 | RF_1143 | TPR repeats. | Aminopeptidase A; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.499 |
| RF_0260 | pepP | RF_0260 | RF_0840 | TPR repeats. | Aminopeptidase P. | 0.530 |
| RF_0260 | rlpA | RF_0260 | RF_0611 | TPR repeats. | Rare lipoprotein A precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.796 |
| RF_1144 | pepA | RF_1144 | RF_1143 | Unknown. | Aminopeptidase A; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.520 |
| aatA | glyA | RF_0074 | RF_1188 | Aspartate aminotransferase A; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.480 |
| aatA | groEL | RF_0074 | RF_0409 | Aspartate aminotransferase A; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.501 |
| aatA | pepA | RF_0074 | RF_1143 | Aspartate aminotransferase A; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Aminopeptidase A; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.830 |
| glyA | aatA | RF_1188 | RF_0074 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aspartate aminotransferase A; Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.480 |
| glyA | gmk | RF_1188 | RF_1229 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.698 |
| glyA | groEL | RF_1188 | RF_0409 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.569 |
| glyA | pepA | RF_1188 | RF_1143 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminopeptidase A; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.825 |
| glyA | rlpA | RF_1188 | RF_0611 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Rare lipoprotein A precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.544 |
| gmk | RF_0260 | RF_1229 | RF_0260 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | TPR repeats. | 0.470 |
| gmk | glyA | RF_1229 | RF_1188 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.698 |
| gmk | pepA | RF_1229 | RF_1143 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Aminopeptidase A; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.632 |
| gmk | rlpA | RF_1229 | RF_0611 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Rare lipoprotein A precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.615 |
| greA | groEL | RF_1360 | RF_0409 | Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.636 |