Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tlyCHemolysin C; Belongs to the UPF0053 family. Hemolysin C subfamily. (299 aa)    
Predicted Functional Partners:
ybeY
Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
  
  
 0.870
pld
Phospholipase D (PLD) superfamily protein; Could be a virulence factor; Belongs to the phospholipase D family.
  
 
 0.819
tlyA
Hemolysin A.
     
 0.771
rompB
Outer membrane protein B; Cell surface antigen Sca5, 168 kDa.
      
 0.763
rickA
Actin polymerization protein RickA; Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.
      
 0.618
lepB
Signal peptidase I; Belongs to the peptidase S26 family.
     
 0.566
RF_0987
Ankyrin repeat.
  
    0.524
cutE
Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.
 
   
 0.495
RF_0915
Methylated-DNA--protein-cysteine methyltransferase.
       0.479
dat
Methylated-DNA--protein-cysteine methyltransferase.
       0.479
Your Current Organism:
Rickettsia felis
NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2
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