tlyC protein (Rickettsia felis) - STRING interaction network

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Score

tlyC

Hemolysin C; Belongs to the UPF0053 family. Hemolysin C subfamily. (299 aa)

Predicted Functional Partners:

ybeY

0.874

tlyA

0.715

pld

0.562

rlpA

0.510

RF_0987

0.480

RF_0915

0.475

dat

0.475

lipA

0.463

glyA

0.457

RF_0310

0.456

Your Current Organism:

Rickettsia felis

NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RF_0310	RF_0987	RF_0310	RF_0987	Tetratricopeptide repeat domain containing protein.	Ankyrin repeat.	0.805
RF_0310	rlpA	RF_0310	RF_0611	Tetratricopeptide repeat domain containing protein.	Rare lipoprotein A precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.	0.665
RF_0310	tlyC	RF_0310	RF_1185	Tetratricopeptide repeat domain containing protein.	Hemolysin C; Belongs to the UPF0053 family. Hemolysin C subfamily.	0.456
RF_0915	dat	RF_0915	RF_0916	Methylated-DNA--protein-cysteine methyltransferase.	Methylated-DNA--protein-cysteine methyltransferase.	0.949
RF_0915	glyA	RF_0915	RF_1188	Methylated-DNA--protein-cysteine methyltransferase.	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.416
RF_0915	tlyC	RF_0915	RF_1185	Methylated-DNA--protein-cysteine methyltransferase.	Hemolysin C; Belongs to the UPF0053 family. Hemolysin C subfamily.	0.475
RF_0987	RF_0310	RF_0987	RF_0310	Ankyrin repeat.	Tetratricopeptide repeat domain containing protein.	0.805
RF_0987	glyA	RF_0987	RF_1188	Ankyrin repeat.	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.492
RF_0987	rlpA	RF_0987	RF_0611	Ankyrin repeat.	Rare lipoprotein A precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.	0.797
RF_0987	tlyC	RF_0987	RF_1185	Ankyrin repeat.	Hemolysin C; Belongs to the UPF0053 family. Hemolysin C subfamily.	0.480
RF_0987	ybeY	RF_0987	RF_1186	Ankyrin repeat.	Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.	0.663
dat	RF_0915	RF_0916	RF_0915	Methylated-DNA--protein-cysteine methyltransferase.	Methylated-DNA--protein-cysteine methyltransferase.	0.949
dat	glyA	RF_0916	RF_1188	Methylated-DNA--protein-cysteine methyltransferase.	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.416
dat	tlyC	RF_0916	RF_1185	Methylated-DNA--protein-cysteine methyltransferase.	Hemolysin C; Belongs to the UPF0053 family. Hemolysin C subfamily.	0.475
glyA	RF_0915	RF_1188	RF_0915	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Methylated-DNA--protein-cysteine methyltransferase.	0.416
glyA	RF_0987	RF_1188	RF_0987	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Ankyrin repeat.	0.492
glyA	dat	RF_1188	RF_0916	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Methylated-DNA--protein-cysteine methyltransferase.	0.416
glyA	lipA	RF_1188	RF_1187	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.824
glyA	pld	RF_1188	RF_1297	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phospholipase D (PLD) superfamily protein; Could be a virulence factor; Belongs to the phospholipase D family.	0.514
glyA	rlpA	RF_1188	RF_0611	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Rare lipoprotein A precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.	0.544