RF_1189 protein (Rickettsia felis) - STRING interaction network

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Score

RF_1189

Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. (215 aa)

Predicted Functional Partners:

RF_1326

0.885

grxC2

0.482

polA

0.477

lipA

0.464

sdhC

0.462

glyA

0.432

nth

0.419

Your Current Organism:

Rickettsia felis

NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RF_1189	RF_1326	RF_1189	RF_1326	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	DAP2-like protein; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases.	0.885
RF_1189	glyA	RF_1189	RF_1188	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.432
RF_1189	grxC2	RF_1189	RF_1190	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	Glutaredoxin-like protein grla; Belongs to the glutaredoxin family. Monothiol subfamily.	0.482
RF_1189	lipA	RF_1189	RF_1187	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.464
RF_1189	nth	RF_1189	RF_1191	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.419
RF_1189	polA	RF_1189	RF_1239	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.477
RF_1189	sdhC	RF_1189	RF_1163	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	Succinate dehydrogenase cytochrome b-556 subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH).	0.462
RF_1326	RF_1189	RF_1326	RF_1189	DAP2-like protein; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases.	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	0.885
glyA	RF_1189	RF_1188	RF_1189	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	0.432
glyA	lipA	RF_1188	RF_1187	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.824
glyA	polA	RF_1188	RF_1239	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.804
grxC2	RF_1189	RF_1190	RF_1189	Glutaredoxin-like protein grla; Belongs to the glutaredoxin family. Monothiol subfamily.	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	0.482
grxC2	lipA	RF_1190	RF_1187	Glutaredoxin-like protein grla; Belongs to the glutaredoxin family. Monothiol subfamily.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.462
grxC2	nth	RF_1190	RF_1191	Glutaredoxin-like protein grla; Belongs to the glutaredoxin family. Monothiol subfamily.	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.561
lipA	RF_1189	RF_1187	RF_1189	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	0.464
lipA	glyA	RF_1187	RF_1188	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.824
lipA	grxC2	RF_1187	RF_1190	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Glutaredoxin-like protein grla; Belongs to the glutaredoxin family. Monothiol subfamily.	0.462
lipA	polA	RF_1187	RF_1239	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.485
nth	RF_1189	RF_1191	RF_1189	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	Serine esterase; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	0.419
nth	grxC2	RF_1191	RF_1190	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	Glutaredoxin-like protein grla; Belongs to the glutaredoxin family. Monothiol subfamily.	0.561