STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
fabF3-oxoacyl-[acyl carrier protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (426 aa)    
Predicted Functional Partners:
fabD
Malonyl CoA-acyl carrier protein transacylase.
 0.999
fabH
3-oxoacyl-[acyl carrier protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 
 0.996
fabI
Enoyl-[acyl carrier protein] reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.
  
 
 0.995
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
  
 
 0.992
fabG
3-oxoacyl reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 0.981
fabZ
(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
 
  
 0.962
fadB
3-hydroxyacyl-CoA dehydrogenase FadB; In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
  
 
 0.954
accC
Acetyl-CoA carboxylase, biotin carboxylase.
 
  
 0.872
aas
2-acylglycerophosphoethanolamine acyltransferase.
  
  
 0.853
pdhB
Pyruvate dehydrogenase E1 component, beta subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
  
 0.824
Your Current Organism:
Rickettsia felis
NCBI taxonomy Id: 315456
Other names: R. felis URRWXCal2, Rickettsia felis URRWXCal2, Rickettsia felis str. URRWXCal2, Rickettsia felis strain URRWXCal2
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