| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RF_1240 | RF_1241 | RF_1240 | RF_1241 | HicB family. | S-adenosylmethionine synthetase MetK. | 0.639 |
| RF_1240 | polA | RF_1240 | RF_1239 | HicB family. | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.423 |
| RF_1241 | RF_1240 | RF_1241 | RF_1240 | S-adenosylmethionine synthetase MetK. | HicB family. | 0.639 |
| RF_1241 | RF_1242 | RF_1241 | RF_1242 | S-adenosylmethionine synthetase MetK. | S-adenosylmethionine synthetase MetK. | 0.986 |
| RF_1241 | glyA | RF_1241 | RF_1188 | S-adenosylmethionine synthetase MetK. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.717 |
| RF_1241 | pheT | RF_1241 | RF_0648 | S-adenosylmethionine synthetase MetK. | Phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.812 |
| RF_1241 | polA | RF_1241 | RF_1239 | S-adenosylmethionine synthetase MetK. | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.744 |
| RF_1241 | pyrG | RF_1241 | RF_0593 | S-adenosylmethionine synthetase MetK. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.475 |
| RF_1241 | recA | RF_1241 | RF_1221 | S-adenosylmethionine synthetase MetK. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.458 |
| RF_1241 | tme | RF_1241 | RF_0584 | S-adenosylmethionine synthetase MetK. | Malate oxidoreductase and phosphate acetyltransferase. | 0.553 |
| RF_1241 | topA | RF_1241 | RF_0530 | S-adenosylmethionine synthetase MetK. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.515 |
| RF_1241 | uvrD | RF_1241 | RF_0687 | S-adenosylmethionine synthetase MetK. | DNA helicase II; Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity); Belongs to the helicase family. UvrD subfamily. | 0.451 |
| RF_1242 | RF_1241 | RF_1242 | RF_1241 | S-adenosylmethionine synthetase MetK. | S-adenosylmethionine synthetase MetK. | 0.986 |
| RF_1242 | glyA | RF_1242 | RF_1188 | S-adenosylmethionine synthetase MetK. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.717 |
| RF_1242 | pheT | RF_1242 | RF_0648 | S-adenosylmethionine synthetase MetK. | Phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.812 |
| RF_1242 | polA | RF_1242 | RF_1239 | S-adenosylmethionine synthetase MetK. | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.701 |
| RF_1242 | pyrG | RF_1242 | RF_0593 | S-adenosylmethionine synthetase MetK. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.475 |
| RF_1242 | recA | RF_1242 | RF_1221 | S-adenosylmethionine synthetase MetK. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.458 |
| RF_1242 | tme | RF_1242 | RF_0584 | S-adenosylmethionine synthetase MetK. | Malate oxidoreductase and phosphate acetyltransferase. | 0.553 |
| RF_1242 | topA | RF_1242 | RF_0530 | S-adenosylmethionine synthetase MetK. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.515 |