node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPUM_0031 | BPUM_2257 | BPUM_0031 | BPUM_2257 | Transcriptional regulator. | Transcriptional repressor CcpN. | 0.410 |
BPUM_0031 | BPUM_2490 | BPUM_0031 | BPUM_2490 | Transcriptional regulator. | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.487 |
BPUM_0031 | BPUM_2572 | BPUM_0031 | BPUM_2572 | Transcriptional regulator. | Hypothetical protein. | 0.675 |
BPUM_0031 | guaA | BPUM_0031 | BPUM_0548 | Transcriptional regulator. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.961 |
BPUM_0031 | guaB | BPUM_0031 | BPUM_0504 | Transcriptional regulator. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.854 |
BPUM_0031 | purA | BPUM_0031 | BPUM_3693 | Transcriptional regulator. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.511 |
BPUM_1464 | BPUM_2490 | BPUM_1464 | BPUM_2490 | ATPase. | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.642 |
BPUM_1464 | BPUM_2572 | BPUM_1464 | BPUM_2572 | ATPase. | Hypothetical protein. | 0.649 |
BPUM_1464 | atpB | BPUM_1464 | BPUM_3332 | ATPase. | ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | 0.642 |
BPUM_1464 | atpE | BPUM_1464 | BPUM_3331 | ATPase. | ATP synthase F0F1 subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.701 |
BPUM_1464 | guaB | BPUM_1464 | BPUM_0504 | ATPase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.613 |
BPUM_2257 | BPUM_0031 | BPUM_2257 | BPUM_0031 | Transcriptional repressor CcpN. | Transcriptional regulator. | 0.410 |
BPUM_2257 | BPUM_2572 | BPUM_2257 | BPUM_2572 | Transcriptional repressor CcpN. | Hypothetical protein. | 0.643 |
BPUM_2257 | guaA | BPUM_2257 | BPUM_0548 | Transcriptional repressor CcpN. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.857 |
BPUM_2257 | guaB | BPUM_2257 | BPUM_0504 | Transcriptional repressor CcpN. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.796 |
BPUM_2257 | purA | BPUM_2257 | BPUM_3693 | Transcriptional repressor CcpN. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.599 |
BPUM_2490 | BPUM_0031 | BPUM_2490 | BPUM_0031 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Transcriptional regulator. | 0.487 |
BPUM_2490 | BPUM_1464 | BPUM_2490 | BPUM_1464 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | ATPase. | 0.642 |
BPUM_2490 | BPUM_2572 | BPUM_2490 | BPUM_2572 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein. | 0.656 |
BPUM_2490 | guaA | BPUM_2490 | BPUM_0548 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.932 |