node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPE_0320 | RPE_0322 | RPE_0320 | RPE_0322 | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | PFAM: transcription activator, effector binding; KEGG: rpc:RPC_0216 transcription activator, effector binding. | 0.544 |
RPE_0320 | RPE_0323 | RPE_0320 | RPE_0323 | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | PFAM: protein of unknown function DUF541; KEGG: rpc:RPC_0217 protein of unknown function DUF541. | 0.544 |
RPE_0320 | RPE_0355 | RPE_0320 | RPE_0355 | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.575 |
RPE_0320 | RPE_0379 | RPE_0320 | RPE_0379 | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | Maf protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.477 |
RPE_0320 | dapF | RPE_0320 | RPE_0321 | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.918 |
RPE_0320 | pnp | RPE_0320 | RPE_0192 | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.576 |
RPE_0320 | prfA | RPE_0320 | RPE_0160 | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.528 |
RPE_0320 | rlmN | RPE_0320 | RPE_0038 | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | Radical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.751 |
RPE_0320 | rph | RPE_0320 | RPE_0353 | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | RNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.545 |
RPE_0320 | tgt | RPE_0320 | RPE_2771 | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.480 |
RPE_0322 | RPE_0320 | RPE_0322 | RPE_0320 | PFAM: transcription activator, effector binding; KEGG: rpc:RPC_0216 transcription activator, effector binding. | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | 0.544 |
RPE_0322 | RPE_0323 | RPE_0322 | RPE_0323 | PFAM: transcription activator, effector binding; KEGG: rpc:RPC_0216 transcription activator, effector binding. | PFAM: protein of unknown function DUF541; KEGG: rpc:RPC_0217 protein of unknown function DUF541. | 0.875 |
RPE_0322 | dapF | RPE_0322 | RPE_0321 | PFAM: transcription activator, effector binding; KEGG: rpc:RPC_0216 transcription activator, effector binding. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.544 |
RPE_0323 | RPE_0320 | RPE_0323 | RPE_0320 | PFAM: protein of unknown function DUF541; KEGG: rpc:RPC_0217 protein of unknown function DUF541. | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | 0.544 |
RPE_0323 | RPE_0322 | RPE_0323 | RPE_0322 | PFAM: protein of unknown function DUF541; KEGG: rpc:RPC_0217 protein of unknown function DUF541. | PFAM: transcription activator, effector binding; KEGG: rpc:RPC_0216 transcription activator, effector binding. | 0.875 |
RPE_0323 | dapF | RPE_0323 | RPE_0321 | PFAM: protein of unknown function DUF541; KEGG: rpc:RPC_0217 protein of unknown function DUF541. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.544 |
RPE_0355 | RPE_0320 | RPE_0355 | RPE_0320 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | KEGG: rpc:RPC_0214 MiaB-like tRNA modifying enzyme; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | 0.575 |
RPE_0355 | RPE_0379 | RPE_0355 | RPE_0379 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Maf protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.411 |
RPE_0355 | pnp | RPE_0355 | RPE_0192 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. | 0.458 |
RPE_0355 | rlmN | RPE_0355 | RPE_0038 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Radical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.712 |