| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPE_0407 | RPE_4416 | RPE_0407 | RPE_4416 | TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding; KEGG: rpc:RPC_0267 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family. | Farnesyltranstransferase; PFAM: Polyprenyl synthetase; KEGG: rpa:RPA1040 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.413 |
| RPE_0407 | ubiA | RPE_0407 | RPE_0875 | TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding; KEGG: rpc:RPC_0267 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.707 |
| RPE_0407 | ubiG | RPE_0407 | RPE_0157 | TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding; KEGG: rpc:RPC_0267 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.972 |
| RPE_0874 | ubiA | RPE_0874 | RPE_0875 | KEGG: rpc:RPC_4712 hypothetical protein. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.875 |
| RPE_1338 | ubiA | RPE_1338 | RPE_0875 | TIGRFAM: geranylgeranyl reductase; PFAM: monooxygenase, FAD-binding; FAD dependent oxidoreductase; KEGG: rpb:RPB_3990 geranylgeranyl reductase. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.874 |
| RPE_3801 | ubiA | RPE_3801 | RPE_0875 | PFAM: thioesterase superfamily protein; KEGG: rpd:RPD_1888 thioesterase superfamily. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.903 |
| RPE_4416 | RPE_0407 | RPE_4416 | RPE_0407 | Farnesyltranstransferase; PFAM: Polyprenyl synthetase; KEGG: rpa:RPA1040 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding; KEGG: rpc:RPC_0267 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family. | 0.413 |
| RPE_4416 | ubiA | RPE_4416 | RPE_0875 | Farnesyltranstransferase; PFAM: Polyprenyl synthetase; KEGG: rpa:RPA1040 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.912 |
| RPE_4416 | ubiX | RPE_4416 | RPE_4743 | Farnesyltranstransferase; PFAM: Polyprenyl synthetase; KEGG: rpa:RPA1040 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.417 |
| RPE_4742 | ubiA | RPE_4742 | RPE_0875 | TIGRFAM: UbiD family decarboxylases; PFAM: Carboxylyase-related protein; KEGG: rpc:RPC_4781 carboxylyase-related protein; Belongs to the UbiD family. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.967 |
| RPE_4742 | ubiX | RPE_4742 | RPE_4743 | TIGRFAM: UbiD family decarboxylases; PFAM: Carboxylyase-related protein; KEGG: rpc:RPC_4781 carboxylyase-related protein; Belongs to the UbiD family. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.999 |
| atpD | atpE | RPE_0280 | RPE_4778 | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. | H+-transporting two-sector ATPase, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.999 |
| atpD | ubiA | RPE_0280 | RPE_0875 | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.757 |
| atpE | atpD | RPE_4778 | RPE_0280 | H+-transporting two-sector ATPase, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. | 0.999 |
| atpE | ubiA | RPE_4778 | RPE_0875 | H+-transporting two-sector ATPase, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.749 |
| ubiA | RPE_0407 | RPE_0875 | RPE_0407 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding; KEGG: rpc:RPC_0267 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family. | 0.707 |
| ubiA | RPE_0874 | RPE_0875 | RPE_0874 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | KEGG: rpc:RPC_4712 hypothetical protein. | 0.875 |
| ubiA | RPE_1338 | RPE_0875 | RPE_1338 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | TIGRFAM: geranylgeranyl reductase; PFAM: monooxygenase, FAD-binding; FAD dependent oxidoreductase; KEGG: rpb:RPB_3990 geranylgeranyl reductase. | 0.874 |
| ubiA | RPE_3801 | RPE_0875 | RPE_3801 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | PFAM: thioesterase superfamily protein; KEGG: rpd:RPD_1888 thioesterase superfamily. | 0.903 |
| ubiA | RPE_4416 | RPE_0875 | RPE_4416 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Farnesyltranstransferase; PFAM: Polyprenyl synthetase; KEGG: rpa:RPA1040 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.912 |