| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPE_0462 | RPE_2098 | RPE_0462 | RPE_2098 | PFAM: Nucleotidyl transferase; KEGG: rpd:RPD_0204 nucleotidyl transferase. | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | 0.459 |
| RPE_0697 | RPE_2098 | RPE_0697 | RPE_2098 | PFAM: major facilitator superfamily MFS_1; KEGG: rpd:RPD_0083 major facilitator superfamily MFS_1. | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | 0.463 |
| RPE_0697 | RPE_2693 | RPE_0697 | RPE_2693 | PFAM: major facilitator superfamily MFS_1; KEGG: rpd:RPD_0083 major facilitator superfamily MFS_1. | Beta-N-acetylhexosaminidase; PFAM: glycoside hydrolase, family 3 domain protein; KEGG: rpb:RPB_2748 beta-N-acetylhexosaminidase. | 0.598 |
| RPE_2070 | RPE_2098 | RPE_2070 | RPE_2098 | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | 0.588 |
| RPE_2098 | RPE_0462 | RPE_2098 | RPE_0462 | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | PFAM: Nucleotidyl transferase; KEGG: rpd:RPD_0204 nucleotidyl transferase. | 0.459 |
| RPE_2098 | RPE_0697 | RPE_2098 | RPE_0697 | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | PFAM: major facilitator superfamily MFS_1; KEGG: rpd:RPD_0083 major facilitator superfamily MFS_1. | 0.463 |
| RPE_2098 | RPE_2070 | RPE_2098 | RPE_2070 | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). | 0.588 |
| RPE_2098 | RPE_2100 | RPE_2098 | RPE_2100 | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | KEGG: rpc:RPC_2187 hypothetical protein. | 0.458 |
| RPE_2098 | RPE_2101 | RPE_2098 | RPE_2101 | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; KEGG: rpc:RPC_2188 peptidoglycan glycosyltransferase. | 0.541 |
| RPE_2098 | RPE_2693 | RPE_2098 | RPE_2693 | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | Beta-N-acetylhexosaminidase; PFAM: glycoside hydrolase, family 3 domain protein; KEGG: rpb:RPB_2748 beta-N-acetylhexosaminidase. | 0.650 |
| RPE_2098 | RPE_3759 | RPE_2098 | RPE_3759 | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | PFAM: NLP/P60 protein; KEGG: bja:bll1430 hypothetical protein. | 0.484 |
| RPE_2098 | anmK | RPE_2098 | RPE_2971 | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.487 |
| RPE_2098 | murD | RPE_2098 | RPE_2105 | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.528 |
| RPE_2098 | rsmH | RPE_2098 | RPE_2099 | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.502 |
| RPE_2100 | RPE_2098 | RPE_2100 | RPE_2098 | KEGG: rpc:RPC_2187 hypothetical protein. | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | 0.458 |
| RPE_2100 | RPE_2101 | RPE_2100 | RPE_2101 | KEGG: rpc:RPC_2187 hypothetical protein. | Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; KEGG: rpc:RPC_2188 peptidoglycan glycosyltransferase. | 0.903 |
| RPE_2100 | murD | RPE_2100 | RPE_2105 | KEGG: rpc:RPC_2187 hypothetical protein. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.405 |
| RPE_2100 | rsmH | RPE_2100 | RPE_2099 | KEGG: rpc:RPC_2187 hypothetical protein. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.875 |
| RPE_2101 | RPE_2098 | RPE_2101 | RPE_2098 | Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; KEGG: rpc:RPC_2188 peptidoglycan glycosyltransferase. | PFAM: Peptidoglycan-binding domain 1 protein; N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: rpc:RPC_2185 negative regulator of AmpC, AmpD. | 0.541 |
| RPE_2101 | RPE_2100 | RPE_2101 | RPE_2100 | Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; KEGG: rpc:RPC_2188 peptidoglycan glycosyltransferase. | KEGG: rpc:RPC_2187 hypothetical protein. | 0.903 |