| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPE_2230 | RPE_2232 | RPE_2230 | RPE_2232 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | 0.436 |
| RPE_2230 | RPE_2234 | RPE_2230 | RPE_2234 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.408 |
| RPE_2230 | cobQ | RPE_2230 | RPE_2238 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.834 |
| RPE_2230 | cobQ-2 | RPE_2230 | RPE_3122 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.834 |
| RPE_2230 | cobS | RPE_2230 | RPE_3123 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.594 |
| RPE_2230 | cobS-2 | RPE_2230 | RPE_3848 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.594 |
| RPE_2230 | cobT | RPE_2230 | RPE_2229 | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.852 |
| RPE_2232 | RPE_2230 | RPE_2232 | RPE_2230 | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | 0.436 |
| RPE_2232 | RPE_2234 | RPE_2232 | RPE_2234 | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.825 |
| RPE_2232 | cobD | RPE_2232 | RPE_2239 | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.543 |
| RPE_2232 | cobQ | RPE_2232 | RPE_2238 | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.520 |
| RPE_2232 | cobQ-2 | RPE_2232 | RPE_3122 | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.521 |
| RPE_2232 | cobS | RPE_2232 | RPE_3123 | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.421 |
| RPE_2232 | cobS-2 | RPE_2232 | RPE_3848 | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.476 |
| RPE_2232 | cobT | RPE_2232 | RPE_2229 | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.987 |
| RPE_2232 | cobT-2 | RPE_2232 | RPE_3845 | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.988 |
| RPE_2234 | RPE_2230 | RPE_2234 | RPE_2230 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | 0.408 |
| RPE_2234 | RPE_2232 | RPE_2234 | RPE_2232 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | KEGG: rpd:RPD_0641 Cob(II)yrinic acid a,c-diamide reductase; TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase. | 0.825 |
| RPE_2234 | RPE_3847 | RPE_2234 | RPE_3847 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | PFAM: Phosphoglycerate mutase; KEGG: rpc:RPC_1895 phosphoglycerate mutase. | 0.710 |
| RPE_2234 | cobD | RPE_2234 | RPE_2239 | Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.993 |