| node1 | node2 | node1 annotation | node2 annotation | score |
| RPE_1763 | RPE_2220 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | KEGG: rpa:RPA2085 cobalamin biosynthesis protein G; CbiG. | 0.536 |
| RPE_1763 | RPE_2221 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | KEGG: rpb:RPB_3182 precorrin-6y C5,15-methyltransferase, subunit CbiE; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Methyltransferase type 12. | 0.833 |
| RPE_1763 | RPE_2222 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | KEGG: rpc:RPC_1885 precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK. | 0.546 |
| RPE_1763 | RPE_2223 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rpc:RPC_1886 precorrin-3B C17-methyltransferase. | 0.626 |
| RPE_1763 | RPE_2224 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rpc:RPC_1887 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.954 |
| RPE_1763 | RPE_2231 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | KEGG: rru:Rru_A0458 hypothetical protein. | 0.454 |
| RPE_1763 | RPE_4291 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: rpc:RPC_1962 ABC transporter related. | 0.436 |
| RPE_1968 | RPE_2220 | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: rpc:RPC_1949 cobalt ABC transporter CbiQ, permease subunit. | KEGG: rpa:RPA2085 cobalamin biosynthesis protein G; CbiG. | 0.594 |
| RPE_1968 | RPE_2221 | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: rpc:RPC_1949 cobalt ABC transporter CbiQ, permease subunit. | KEGG: rpb:RPB_3182 precorrin-6y C5,15-methyltransferase, subunit CbiE; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Methyltransferase type 12. | 0.571 |
| RPE_1968 | RPE_2222 | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: rpc:RPC_1949 cobalt ABC transporter CbiQ, permease subunit. | KEGG: rpc:RPC_1885 precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK. | 0.404 |
| RPE_1968 | RPE_2231 | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: rpc:RPC_1949 cobalt ABC transporter CbiQ, permease subunit. | KEGG: rru:Rru_A0458 hypothetical protein. | 0.882 |
| RPE_1968 | RPE_4291 | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: rpc:RPC_1949 cobalt ABC transporter CbiQ, permease subunit. | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: rpc:RPC_1962 ABC transporter related. | 0.998 |
| RPE_1968 | RPE_4292 | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: rpc:RPC_1949 cobalt ABC transporter CbiQ, permease subunit. | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: rpc:RPC_1961 cobalt ABC transporter CbiQ, permease subunit. | 0.906 |
| RPE_2220 | RPE_1763 | KEGG: rpa:RPA2085 cobalamin biosynthesis protein G; CbiG. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.536 |
| RPE_2220 | RPE_1968 | KEGG: rpa:RPA2085 cobalamin biosynthesis protein G; CbiG. | TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; KEGG: rpc:RPC_1949 cobalt ABC transporter CbiQ, permease subunit. | 0.594 |
| RPE_2220 | RPE_2221 | KEGG: rpa:RPA2085 cobalamin biosynthesis protein G; CbiG. | KEGG: rpb:RPB_3182 precorrin-6y C5,15-methyltransferase, subunit CbiE; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Methyltransferase type 12. | 0.994 |
| RPE_2220 | RPE_2222 | KEGG: rpa:RPA2085 cobalamin biosynthesis protein G; CbiG. | KEGG: rpc:RPC_1885 precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK. | 0.979 |
| RPE_2220 | RPE_2223 | KEGG: rpa:RPA2085 cobalamin biosynthesis protein G; CbiG. | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rpc:RPC_1886 precorrin-3B C17-methyltransferase. | 0.957 |
| RPE_2220 | RPE_2224 | KEGG: rpa:RPA2085 cobalamin biosynthesis protein G; CbiG. | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rpc:RPC_1887 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.950 |
| RPE_2220 | RPE_2231 | KEGG: rpa:RPA2085 cobalamin biosynthesis protein G; CbiG. | KEGG: rru:Rru_A0458 hypothetical protein. | 0.656 |