| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPE_1359 | RPE_2810 | RPE_1359 | RPE_2810 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.469 |
| RPE_1359 | RPE_3191 | RPE_1359 | RPE_3191 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | PFAM: Radical SAM domain protein; KEGG: rpa:RPA2614 hypothetical protein. | 0.745 |
| RPE_1359 | RPE_3402 | RPE_1359 | RPE_3402 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: nha:Nham_2814 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.758 |
| RPE_1359 | RPE_4787 | RPE_1359 | RPE_4787 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | KEGG: rpa:RPA0854 5-aminolevulinic acid synthase (ALAS); TIGRFAM: 5-aminolevulinic acid synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; aminotransferase class-III. | 0.902 |
| RPE_1359 | bioB | RPE_1359 | RPE_2208 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.816 |
| RPE_1359 | bioD | RPE_1359 | RPE_3401 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.918 |
| RPE_2810 | RPE_1359 | RPE_2810 | RPE_1359 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | 0.469 |
| RPE_2810 | RPE_3191 | RPE_2810 | RPE_3191 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: Radical SAM domain protein; KEGG: rpa:RPA2614 hypothetical protein. | 0.442 |
| RPE_2810 | RPE_3400 | RPE_2810 | RPE_3400 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: nha:Nham_2816 8-amino-7-oxononanoate synthase. | 0.469 |
| RPE_2810 | RPE_3402 | RPE_2810 | RPE_3402 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: nha:Nham_2814 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.448 |
| RPE_2810 | RPE_4787 | RPE_2810 | RPE_4787 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: rpa:RPA0854 5-aminolevulinic acid synthase (ALAS); TIGRFAM: 5-aminolevulinic acid synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; aminotransferase class-III. | 0.469 |
| RPE_2810 | bioB | RPE_2810 | RPE_2208 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.442 |
| RPE_2810 | bioD | RPE_2810 | RPE_3401 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.460 |
| RPE_2810 | nadE-2 | RPE_2810 | RPE_1993 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.787 |
| RPE_3191 | RPE_1359 | RPE_3191 | RPE_1359 | PFAM: Radical SAM domain protein; KEGG: rpa:RPA2614 hypothetical protein. | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | 0.745 |
| RPE_3191 | RPE_2810 | RPE_3191 | RPE_2810 | PFAM: Radical SAM domain protein; KEGG: rpa:RPA2614 hypothetical protein. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.442 |
| RPE_3191 | RPE_3400 | RPE_3191 | RPE_3400 | PFAM: Radical SAM domain protein; KEGG: rpa:RPA2614 hypothetical protein. | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: nha:Nham_2816 8-amino-7-oxononanoate synthase. | 0.745 |
| RPE_3191 | RPE_3402 | RPE_3191 | RPE_3402 | PFAM: Radical SAM domain protein; KEGG: rpa:RPA2614 hypothetical protein. | Aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: nha:Nham_2814 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.815 |
| RPE_3191 | RPE_4787 | RPE_3191 | RPE_4787 | PFAM: Radical SAM domain protein; KEGG: rpa:RPA2614 hypothetical protein. | KEGG: rpa:RPA0854 5-aminolevulinic acid synthase (ALAS); TIGRFAM: 5-aminolevulinic acid synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; aminotransferase class-III. | 0.745 |
| RPE_3191 | bioD | RPE_3191 | RPE_3401 | PFAM: Radical SAM domain protein; KEGG: rpa:RPA2614 hypothetical protein. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.908 |