| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPE_2501 | RPE_3026 | RPE_2501 | RPE_3026 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.919 |
| RPE_2501 | RPE_3057 | RPE_2501 | RPE_3057 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | PFAM: pyruvate kinase; KEGG: rpc:RPC_2956 pyruvate kinase; Belongs to the pyruvate kinase family. | 0.910 |
| RPE_2501 | RPE_3733 | RPE_2501 | RPE_3733 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region; KEGG: rpa:RPA3661 metal dependent phosphohydrolase. | 0.903 |
| RPE_2501 | RPE_4110 | RPE_2501 | RPE_4110 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | PFAM: pyruvate kinase; KEGG: rpa:RPA4193 pyruvate kinase; Belongs to the pyruvate kinase family. | 0.910 |
| RPE_2501 | gmk | RPE_2501 | RPE_3301 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.922 |
| RPE_2501 | ndk | RPE_2501 | RPE_3287 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.922 |
| RPE_2885 | RPE_3026 | RPE_2885 | RPE_3026 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_2752 MazG family protein. | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.931 |
| RPE_2885 | RPE_3057 | RPE_2885 | RPE_3057 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_2752 MazG family protein. | PFAM: pyruvate kinase; KEGG: rpc:RPC_2956 pyruvate kinase; Belongs to the pyruvate kinase family. | 0.900 |
| RPE_2885 | RPE_3733 | RPE_2885 | RPE_3733 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_2752 MazG family protein. | PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region; KEGG: rpa:RPA3661 metal dependent phosphohydrolase. | 0.931 |
| RPE_2885 | RPE_4110 | RPE_2885 | RPE_4110 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_2752 MazG family protein. | PFAM: pyruvate kinase; KEGG: rpa:RPA4193 pyruvate kinase; Belongs to the pyruvate kinase family. | 0.900 |
| RPE_2885 | RPE_4549 | RPE_2885 | RPE_4549 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_2752 MazG family protein. | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; histidine kinase, HAMP region domain protein; KEGG: rpa:RPA1965 putative adenylate/guanylate cyclase. | 0.911 |
| RPE_2885 | ndk | RPE_2885 | RPE_3287 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_2752 MazG family protein. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.900 |
| RPE_3026 | RPE_2501 | RPE_3026 | RPE_2501 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.919 |
| RPE_3026 | RPE_2885 | RPE_3026 | RPE_2885 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_2752 MazG family protein. | 0.931 |
| RPE_3026 | RPE_3057 | RPE_3026 | RPE_3057 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | PFAM: pyruvate kinase; KEGG: rpc:RPC_2956 pyruvate kinase; Belongs to the pyruvate kinase family. | 0.906 |
| RPE_3026 | RPE_3273 | RPE_3026 | RPE_3273 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | PFAM: Ppx/GppA phosphatase; KEGG: rpd:RPD_2258 Ppx/GppA phosphatase. | 0.938 |
| RPE_3026 | RPE_3280 | RPE_3026 | RPE_3280 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | PFAM: Ppx/GppA phosphatase; KEGG: rpc:RPC_2330 Ppx/GppA phosphatase. | 0.939 |
| RPE_3026 | RPE_3733 | RPE_3026 | RPE_3733 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region; KEGG: rpa:RPA3661 metal dependent phosphohydrolase. | 0.918 |
| RPE_3026 | RPE_4110 | RPE_3026 | RPE_4110 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | PFAM: pyruvate kinase; KEGG: rpa:RPA4193 pyruvate kinase; Belongs to the pyruvate kinase family. | 0.906 |
| RPE_3026 | RPE_4549 | RPE_3026 | RPE_4549 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; histidine kinase, HAMP region domain protein; KEGG: rpa:RPA1965 putative adenylate/guanylate cyclase. | 0.909 |