| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPE_2810 | RPE_4357 | RPE_2810 | RPE_4357 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.999 |
| RPE_2810 | RPE_4366 | RPE_2810 | RPE_4366 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: rpc:RPC_4318 ModD protein; TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | 0.636 |
| RPE_2810 | nadA | RPE_2810 | RPE_4400 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.707 |
| RPE_2810 | nadD | RPE_2810 | RPE_0267 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.770 |
| RPE_2810 | nadE-2 | RPE_2810 | RPE_1993 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.689 |
| RPE_2810 | ribH-2 | RPE_2810 | RPE_2812 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.993 |
| RPE_4357 | RPE_2810 | RPE_4357 | RPE_2810 | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
| RPE_4357 | RPE_4366 | RPE_4357 | RPE_4366 | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | KEGG: rpc:RPC_4318 ModD protein; TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | 0.587 |
| RPE_4357 | nadA | RPE_4357 | RPE_4400 | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.535 |
| RPE_4357 | nadD | RPE_4357 | RPE_0267 | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.575 |
| RPE_4357 | nadE-2 | RPE_4357 | RPE_1993 | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.666 |
| RPE_4357 | ribH-2 | RPE_4357 | RPE_2812 | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
| RPE_4365 | RPE_4366 | RPE_4365 | RPE_4366 | PFAM: regulatory protein, LysR; KEGG: rpc:RPC_4319 putative transcriptional regulator, ModE family. | KEGG: rpc:RPC_4318 ModD protein; TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | 0.643 |
| RPE_4366 | RPE_2810 | RPE_4366 | RPE_2810 | KEGG: rpc:RPC_4318 ModD protein; TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.636 |
| RPE_4366 | RPE_4357 | RPE_4366 | RPE_4357 | KEGG: rpc:RPC_4318 ModD protein; TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.587 |
| RPE_4366 | RPE_4365 | RPE_4366 | RPE_4365 | KEGG: rpc:RPC_4318 ModD protein; TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | PFAM: regulatory protein, LysR; KEGG: rpc:RPC_4319 putative transcriptional regulator, ModE family. | 0.643 |
| RPE_4366 | RPE_4395 | RPE_4366 | RPE_4395 | KEGG: rpc:RPC_4318 ModD protein; TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | KEGG: rpc:RPC_4335 hypothetical protein. | 0.802 |
| RPE_4366 | RPE_4401 | RPE_4366 | RPE_4401 | KEGG: rpc:RPC_4318 ModD protein; TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. | 0.965 |
| RPE_4366 | RPE_4521 | RPE_4366 | RPE_4521 | KEGG: rpc:RPC_4318 ModD protein; TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | Aminotransferase, class V; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. | 0.578 |
| RPE_4366 | nadA | RPE_4366 | RPE_4400 | KEGG: rpc:RPC_4318 ModD protein; TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.985 |