node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPC_2089 | RPC_3253 | RPC_2089 | RPC_3253 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, small subunit. | 0.966 |
RPC_2089 | RPC_4450 | RPC_2089 | RPC_4450 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.923 |
RPC_2089 | RPC_4630 | RPC_2089 | RPC_4630 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Tartrate dehydrogenase. | 0.838 |
RPC_2089 | ilvC | RPC_2089 | RPC_3248 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.901 |
RPC_2089 | ilvD | RPC_2089 | RPC_2494 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.975 |
RPC_2089 | ilvD-2 | RPC_2089 | RPC_4321 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.974 |
RPC_2089 | leuA | RPC_2089 | RPC_3235 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.922 |
RPC_2089 | leuB | RPC_2089 | RPC_0240 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.889 |
RPC_2089 | leuC | RPC_2089 | RPC_0227 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.990 |
RPC_2089 | leuD | RPC_2089 | RPC_0230 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.990 |
RPC_3253 | RPC_2089 | RPC_3253 | RPC_2089 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.966 |
RPC_3253 | RPC_4450 | RPC_3253 | RPC_4450 | Acetolactate synthase, small subunit. | Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.827 |
RPC_3253 | RPC_4630 | RPC_3253 | RPC_4630 | Acetolactate synthase, small subunit. | Tartrate dehydrogenase. | 0.987 |
RPC_3253 | ilvC | RPC_3253 | RPC_3248 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.997 |
RPC_3253 | ilvD | RPC_3253 | RPC_2494 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.862 |
RPC_3253 | ilvD-2 | RPC_3253 | RPC_4321 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.827 |
RPC_3253 | leuA | RPC_3253 | RPC_3235 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.965 |
RPC_3253 | leuB | RPC_3253 | RPC_0240 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.993 |
RPC_3253 | leuC | RPC_3253 | RPC_0227 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.939 |
RPC_3253 | leuD | RPC_3253 | RPC_0230 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.935 |