node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPC_0260 | RPC_0536 | RPC_0260 | RPC_0536 | Molecular chaperone, Hsp70 class. | Heat shock protein DnaJ-like. | 0.969 |
RPC_0260 | RPC_1138 | RPC_0260 | RPC_1138 | Molecular chaperone, Hsp70 class. | Chaperone DnaJ-like. | 0.972 |
RPC_0260 | RPC_3329 | RPC_0260 | RPC_3329 | Molecular chaperone, Hsp70 class. | Heat shock protein DnaJ-like. | 0.968 |
RPC_0260 | clpP | RPC_0260 | RPC_2392 | Molecular chaperone, Hsp70 class. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.857 |
RPC_0260 | dnaJ | RPC_0260 | RPC_0330 | Molecular chaperone, Hsp70 class. | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.976 |
RPC_0260 | groL1 | RPC_0260 | RPC_3172 | Molecular chaperone, Hsp70 class. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.929 |
RPC_0260 | groL2 | RPC_0260 | RPC_4726 | Molecular chaperone, Hsp70 class. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.929 |
RPC_0260 | grpE | RPC_0260 | RPC_0327 | Molecular chaperone, Hsp70 class. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.983 |
RPC_0260 | hrcA | RPC_0260 | RPC_0326 | Molecular chaperone, Hsp70 class. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.891 |
RPC_0536 | RPC_0260 | RPC_0536 | RPC_0260 | Heat shock protein DnaJ-like. | Molecular chaperone, Hsp70 class. | 0.969 |
RPC_0536 | clpP | RPC_0536 | RPC_2392 | Heat shock protein DnaJ-like. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.522 |
RPC_0536 | dnaK | RPC_0536 | RPC_0329 | Heat shock protein DnaJ-like. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.972 |
RPC_0536 | groL1 | RPC_0536 | RPC_3172 | Heat shock protein DnaJ-like. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.786 |
RPC_0536 | groL2 | RPC_0536 | RPC_4726 | Heat shock protein DnaJ-like. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.786 |
RPC_0536 | grpE | RPC_0536 | RPC_0327 | Heat shock protein DnaJ-like. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.919 |
RPC_0536 | hrcA | RPC_0536 | RPC_0326 | Heat shock protein DnaJ-like. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.867 |
RPC_1138 | RPC_0260 | RPC_1138 | RPC_0260 | Chaperone DnaJ-like. | Molecular chaperone, Hsp70 class. | 0.972 |
RPC_1138 | clpP | RPC_1138 | RPC_2392 | Chaperone DnaJ-like. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.544 |
RPC_1138 | dnaK | RPC_1138 | RPC_0329 | Chaperone DnaJ-like. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.993 |
RPC_1138 | groL1 | RPC_1138 | RPC_3172 | Chaperone DnaJ-like. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.850 |