| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPD_0469 | RPD_1379 | RPD_0469 | RPD_1379 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.971 |
| RPD_0469 | RPD_2312 | RPD_0469 | RPD_2312 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase. | 0.927 |
| RPD_0469 | RPD_3772 | RPD_0469 | RPD_3772 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.994 |
| RPD_0469 | cysC | RPD_0469 | RPD_1153 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Sulfate adenylyltransferase subunit 1 / adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.716 |
| RPD_0469 | hemE | RPD_0469 | RPD_3769 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.940 |
| RPD_1154 | RPD_1155 | RPD_1154 | RPD_1155 | Sulfate adenylyltransferase subunit 2. | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | 0.990 |
| RPD_1154 | RPD_1379 | RPD_1154 | RPD_1379 | Sulfate adenylyltransferase subunit 2. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.954 |
| RPD_1154 | RPD_1381 | RPD_1154 | RPD_1381 | Sulfate adenylyltransferase subunit 2. | Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like. | 0.953 |
| RPD_1154 | RPD_2312 | RPD_1154 | RPD_2312 | Sulfate adenylyltransferase subunit 2. | uroporphyrinogen-III C-methyltransferase. | 0.788 |
| RPD_1154 | cysC | RPD_1154 | RPD_1153 | Sulfate adenylyltransferase subunit 2. | Sulfate adenylyltransferase subunit 1 / adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.999 |
| RPD_1155 | RPD_1154 | RPD_1155 | RPD_1154 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | Sulfate adenylyltransferase subunit 2. | 0.990 |
| RPD_1155 | RPD_1379 | RPD_1155 | RPD_1379 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.976 |
| RPD_1155 | RPD_1380 | RPD_1155 | RPD_1380 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | Conserved hypothetical protein. | 0.524 |
| RPD_1155 | RPD_1381 | RPD_1155 | RPD_1381 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like. | 0.999 |
| RPD_1155 | RPD_2312 | RPD_1155 | RPD_2312 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | uroporphyrinogen-III C-methyltransferase. | 0.874 |
| RPD_1155 | cysC | RPD_1155 | RPD_1153 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | Sulfate adenylyltransferase subunit 1 / adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.999 |
| RPD_1379 | RPD_0469 | RPD_1379 | RPD_0469 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.971 |
| RPD_1379 | RPD_1154 | RPD_1379 | RPD_1154 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfate adenylyltransferase subunit 2. | 0.954 |
| RPD_1379 | RPD_1155 | RPD_1379 | RPD_1155 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. | 0.976 |
| RPD_1379 | RPD_1380 | RPD_1379 | RPD_1380 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Conserved hypothetical protein. | 0.946 |