| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPD_0875 | RPD_2589 | RPD_0875 | RPD_2589 | Glutamate synthase (NADH) large subunit. | Signal transduction histidine kinase, nitrogen specific, NtrB. | 0.452 |
| RPD_0875 | RPD_2901 | RPD_0875 | RPD_2901 | Glutamate synthase (NADH) large subunit. | L-glutamine synthetase. | 0.972 |
| RPD_0875 | glnD | RPD_0875 | RPD_0116 | Glutamate synthase (NADH) large subunit. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. | 0.678 |
| RPD_0875 | glnE | RPD_0875 | RPD_2014 | Glutamate synthase (NADH) large subunit. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.622 |
| RPD_0875 | guaA | RPD_0875 | RPD_2269 | Glutamate synthase (NADH) large subunit. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.738 |
| RPD_0875 | nadE | RPD_0875 | RPD_2060 | Glutamate synthase (NADH) large subunit. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.650 |
| RPD_2011 | RPD_2012 | RPD_2011 | RPD_2012 | Peptidase S1C, Do; Belongs to the peptidase S1C family. | Two component transcriptional regulator, winged helix family. | 0.629 |
| RPD_2011 | RPD_2013 | RPD_2011 | RPD_2013 | Peptidase S1C, Do; Belongs to the peptidase S1C family. | ATP-binding region, ATPase-like. | 0.561 |
| RPD_2011 | glnE | RPD_2011 | RPD_2014 | Peptidase S1C, Do; Belongs to the peptidase S1C family. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.456 |
| RPD_2012 | RPD_2011 | RPD_2012 | RPD_2011 | Two component transcriptional regulator, winged helix family. | Peptidase S1C, Do; Belongs to the peptidase S1C family. | 0.629 |
| RPD_2012 | RPD_2013 | RPD_2012 | RPD_2013 | Two component transcriptional regulator, winged helix family. | ATP-binding region, ATPase-like. | 0.977 |
| RPD_2012 | glnE | RPD_2012 | RPD_2014 | Two component transcriptional regulator, winged helix family. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.862 |
| RPD_2013 | RPD_2011 | RPD_2013 | RPD_2011 | ATP-binding region, ATPase-like. | Peptidase S1C, Do; Belongs to the peptidase S1C family. | 0.561 |
| RPD_2013 | RPD_2012 | RPD_2013 | RPD_2012 | ATP-binding region, ATPase-like. | Two component transcriptional regulator, winged helix family. | 0.977 |
| RPD_2013 | glnE | RPD_2013 | RPD_2014 | ATP-binding region, ATPase-like. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.872 |
| RPD_2448 | glnE | RPD_2448 | RPD_2014 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.662 |
| RPD_2589 | RPD_0875 | RPD_2589 | RPD_0875 | Signal transduction histidine kinase, nitrogen specific, NtrB. | Glutamate synthase (NADH) large subunit. | 0.452 |
| RPD_2589 | RPD_2901 | RPD_2589 | RPD_2901 | Signal transduction histidine kinase, nitrogen specific, NtrB. | L-glutamine synthetase. | 0.418 |
| RPD_2589 | glnD | RPD_2589 | RPD_0116 | Signal transduction histidine kinase, nitrogen specific, NtrB. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. | 0.621 |
| RPD_2589 | glnE | RPD_2589 | RPD_2014 | Signal transduction histidine kinase, nitrogen specific, NtrB. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.514 |
