| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPD_2024 | RPD_2025 | RPD_2024 | RPD_2025 | Protein of unknown function DUF112, transmembrane. | Conserved hypothetical protein. | 0.953 |
| RPD_2024 | RPD_3355 | RPD_2024 | RPD_3355 | Protein of unknown function DUF112, transmembrane. | Uncharacterized protein UPF0065. | 0.869 |
| RPD_2024 | RPD_3356 | RPD_2024 | RPD_3356 | Protein of unknown function DUF112, transmembrane. | Uncharacterized protein UPF0065. | 0.869 |
| RPD_2024 | RPD_3357 | RPD_2024 | RPD_3357 | Protein of unknown function DUF112, transmembrane. | Protein of unknown function DUF112, transmembrane. | 0.909 |
| RPD_2024 | RPD_3358 | RPD_2024 | RPD_3358 | Protein of unknown function DUF112, transmembrane. | Protein of unknown function DUF1468. | 0.755 |
| RPD_2025 | RPD_2024 | RPD_2025 | RPD_2024 | Conserved hypothetical protein. | Protein of unknown function DUF112, transmembrane. | 0.953 |
| RPD_2025 | RPD_3355 | RPD_2025 | RPD_3355 | Conserved hypothetical protein. | Uncharacterized protein UPF0065. | 0.591 |
| RPD_2025 | RPD_3356 | RPD_2025 | RPD_3356 | Conserved hypothetical protein. | Uncharacterized protein UPF0065. | 0.610 |
| RPD_2025 | RPD_3357 | RPD_2025 | RPD_3357 | Conserved hypothetical protein. | Protein of unknown function DUF112, transmembrane. | 0.769 |
| RPD_2025 | RPD_3358 | RPD_2025 | RPD_3358 | Conserved hypothetical protein. | Protein of unknown function DUF1468. | 0.913 |
| RPD_3352 | RPD_3353 | RPD_3352 | RPD_3353 | HflK protein; HflC and HflK could encode or regulate a protease. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.597 |
| RPD_3352 | RPD_3355 | RPD_3352 | RPD_3355 | HflK protein; HflC and HflK could encode or regulate a protease. | Uncharacterized protein UPF0065. | 0.401 |
| RPD_3352 | thyA | RPD_3352 | RPD_3354 | HflK protein; HflC and HflK could encode or regulate a protease. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.625 |
| RPD_3353 | RPD_3352 | RPD_3353 | RPD_3352 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | HflK protein; HflC and HflK could encode or regulate a protease. | 0.597 |
| RPD_3353 | RPD_3355 | RPD_3353 | RPD_3355 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Uncharacterized protein UPF0065. | 0.478 |
| RPD_3353 | thyA | RPD_3353 | RPD_3354 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| RPD_3355 | RPD_2024 | RPD_3355 | RPD_2024 | Uncharacterized protein UPF0065. | Protein of unknown function DUF112, transmembrane. | 0.869 |
| RPD_3355 | RPD_2025 | RPD_3355 | RPD_2025 | Uncharacterized protein UPF0065. | Conserved hypothetical protein. | 0.591 |
| RPD_3355 | RPD_3352 | RPD_3355 | RPD_3352 | Uncharacterized protein UPF0065. | HflK protein; HflC and HflK could encode or regulate a protease. | 0.401 |
| RPD_3355 | RPD_3353 | RPD_3355 | RPD_3353 | Uncharacterized protein UPF0065. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.478 |