Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (516 aa)    
Predicted Functional Partners:
leuD
Isopropylmalate/citramalate isomerase, small subunit; Belongs to the LeuD family.
 
 
 0.991
leuC
Isopropylmalate/citramalate isomerase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.990
ilvE
Branched-chain amino acid aminotransferase.
  
 0.980
ilvD
(R)-2,3-dihydroxy-3-methylbutanoate/(R)-2, 3-dihydroxy-3-methylpentanoate dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.979
ilvI
(S)-2-acetolactate/(S)-2-aceto-2- hydroxybutanoate synthase, biosynthetic type, large subunit.
 
 
 0.968
accC
acetyl-CoA carboxylase, biotin carboxylase component; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.959
ilvH
(S)-2-acetolactate/(S)-2-aceto-2- hydroxybutanoate synthase, biosynthetic type, small subunit.
 
 
 0.958
leuB
3-isopropylmalate/3-methylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 
 0.946
por
Pyruvate:ferredoxin/flavodoxin oxidoreductase.
  
 
 0.942
bamN
Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.924
Your Current Organism:
Geobacter daltonii
NCBI taxonomy Id: 316067
Other names: G. daltonii FRC-32, Geobacter daltonii FRC-32, Geobacter daltonii str. FRC-32, Geobacter daltonii strain FRC-32, Geobacter sp. FRC-32
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.